NEUTROPHILS, CYTOKINES AND CYTOKINE RECEPTORS IN SEPTIC SHOCK

感染性休克中的中性粒细胞、细胞因子和细胞因子受体

• 批准号: 3789306
• 负责人: CHARLES E MCCALL
• 金额: --
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789306
• 关键词: cytokine receptors; endotoxins; enzyme linked immunosorbent assay; gene expression; human subject; interleukin 1; leukocytosis; molecular pathology; neutrophil; pathologic process; phenotype; receptor expression; shock; tumor necrosis factor alpha; virus infection mechanism

This study investigated the molecular mechanisms responsible for tolerance to endotoxin-induced expression of the interleukin-1 Alpha and tumor necrosis factor Alpha genes that occur in circulating leukocytes of patients with the acute disseminated inflammatory syndrome associated with septic shock. These two genes and their secreted proteins play a central role in the pathogenesis of the septic shock syndrome.

这项研究探讨了致病的分子机制。 对内毒素诱导的IL-1α和IL-1α表达的耐受 存在于循环白细胞中的肿瘤坏死因子α基因 与急性播散性炎症综合征相关的患者 感染性休克。这两个基因及其分泌的蛋白在 在感染性休克综合征的发病机制中起中心作用。