BONE AND MINERAL METABOLISM IN BLACKS AND WHITES

黑人和白人的骨骼和矿物质代谢

• 批准号: 3788161
• 负责人: NORMAN H. BELL
• 金额: --
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3788161
• 关键词: 1,25 dihydroxycholecalciferol; 25 hydroxycholecalciferol; African American; blood chemistry; bone density; bone metabolism; calcium metabolism; caucasian American; cyclic AMP; disease /disorder proneness /risk; hormone regulation /control mechanism; human subject; parathyroid hormones; racial /ethnic difference; urinalysis

Blacks are known to have an incidence of hip fractures that is one third that of whites. Studies are going to determine the mechanism for greater bone mass that occurs in blacks. Results to date indicate that blacks have a low rate of bone turnover as compared to whites and alteration of the vitamin D-endocrine system, increases in serum immunoreactive PTH, serum 1,25(OH)2D and urinary cyclic AMP and decreases in serum 25-OHD and urinary calcium.

据了解，黑人髋部骨折的发病率是三分之一， 白人的。 研究将确定更大的 黑人的骨量 迄今为止的结果表明， 与白人相比， 维生素D-内分泌系统，血清免疫反应性PTH增加， 血清1，25（OH）2D和尿环AMP以及血清25-OHD和 尿钙