Influence of an alimentary supplementation with 25-hydroxycholecalciferol on ovine calcium homeostasis

膳食补充剂 25-羟基胆钙化醇对绵羊钙稳态的影响

基本信息

批准号：
223506145
负责人：
Professorin Dr. Mirja Rosmarie Wilkens
金额：
--
依托单位：
Institut für Tierernährung, Ernährungsschäden und Diätetik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2012
资助国家：
德国
起止时间：
2011-12-31 至 2014-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/223506145?language=en
关键词：
Influence alimentary supplementation 25 hydroxycholecalciferol

项目摘要

Peripartal hypocalcemia is a common problem in dairy cows. Although hypocalcemic animals do not always develop clinical milk fever, the transient decrease in plasma calcium concentration predisposes the animals towards various health problems and diseases. Recently, our group could demonstrate that the oral supplementation with the vitamin D metabolite 25-hydroxycholecalciferol could be a promising concept to stabilize peripartal calcium homeostasis. As the mentioned study was carried out in a commercial dairy herd, the facilities to characterize the mechanisms mediating the observed physiological effects were limited. The herewith submitted project is designed to determine the effects of 25-hydroxycholecalciferol on the gastrointestinal tract, the kidney and the skeleton, the organs which are crucial for the regulation of calcium homeostasis. Sheep will be used as an animal model for the investigations which include in vivo-balance studies as well as functional and structural studies focusing on the epithelial and cellular level. Taking advantage of an animal experiment carried out under standardized conditions we hope to verify our hypotheses on the putative effects of 25-hydroxycholecalciferol in order to obtain basic information necessary to develop an innovative concept to stabilize peripartal macromineral homeostasis in dairy cows.

多核低钙血症是奶牛的常见问题。尽管低钙血症动物并不总是会出现临床牛奶热，但血浆钙浓度的瞬时降低使动物偏爱各种健康问题和疾病。最近，我们的小组可以证明，对维生素D代谢产物25-羟基核酸核酸酚的口服补充可能是稳定围角钙稳态的有前途的概念。由于上述研究是在商业奶牛群中进行的，因此表征介导观察到的生理效应的机制的设施受到限制。本文提交的项目旨在确定25-羟基胆碱核酸对胃肠道，肾脏和骨骼的影响，这对于调节钙稳态至关重要。绵羊将被用作研究的动物模型，其中包括体内平衡研究以及着重于上皮和细胞水平的功能和结构研究。利用在标准化条件下进行的动物实验，我们希望验证我们对25-羟基氯基核酸酚的推定影响的假设，以便获得开发创新概念所必需的基本信息，以稳定奶牛中的围绕毛皮的毛骨管大氨基盐稳态。