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Influence of an alimentary supplementation with 25-hydroxycholecalciferol on ovine calcium homeostasis

膳食补充剂 25-羟基胆钙化醇对绵羊钙稳态的影响

基本信息

批准号：
223506145
负责人：
Professorin Dr. Mirja Rosmarie Wilkens
金额：
--
依托单位：
Institut für Tierernährung, Ernährungsschäden und Diätetik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2012
资助国家：
德国
起止时间：
2011-12-31 至 2014-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/223506145?language=en
关键词：
Influence alimentary supplementation 25 hydroxycholecalciferol

项目摘要

Peripartal hypocalcemia is a common problem in dairy cows. Although hypocalcemic animals do not always develop clinical milk fever, the transient decrease in plasma calcium concentration predisposes the animals towards various health problems and diseases. Recently, our group could demonstrate that the oral supplementation with the vitamin D metabolite 25-hydroxycholecalciferol could be a promising concept to stabilize peripartal calcium homeostasis. As the mentioned study was carried out in a commercial dairy herd, the facilities to characterize the mechanisms mediating the observed physiological effects were limited. The herewith submitted project is designed to determine the effects of 25-hydroxycholecalciferol on the gastrointestinal tract, the kidney and the skeleton, the organs which are crucial for the regulation of calcium homeostasis. Sheep will be used as an animal model for the investigations which include in vivo-balance studies as well as functional and structural studies focusing on the epithelial and cellular level. Taking advantage of an animal experiment carried out under standardized conditions we hope to verify our hypotheses on the putative effects of 25-hydroxycholecalciferol in order to obtain basic information necessary to develop an innovative concept to stabilize peripartal macromineral homeostasis in dairy cows.

围产期低钙血症是奶牛常见的问题。虽然低钙动物并不总是出现临床产奶热，但血浆钙浓度的短暂降低使动物易于出现各种健康问题和疾病。最近，我们的小组可以证明，口服补充维生素D代谢产物25-羟基胆钙化醇可能是一个有前途的概念，以稳定围产期钙稳态。由于上述研究是在商业奶牛群中进行的，因此表征介导观察到的生理效应的机制的设施有限。本文提交的项目旨在确定25-羟基胆钙化醇对胃肠道、肾脏和骨骼的影响，这些器官对钙稳态的调节至关重要。绵羊将用作研究的动物模型，包括体内平衡研究以及侧重于上皮和细胞水平的功能和结构研究。利用在标准化条件下进行的动物实验，我们希望验证我们对25-羟基胆钙化醇的推定作用的假设，以获得必要的基本信息，开发一个创新的概念，以稳定奶牛围产期大量矿物质的体内平衡。