ZIDOVUDINE VS DIDEOXYINOSINE VS ZDV PLUS DDI IN HIV-INFECTED CHILDREN

齐多夫定 VS 双脱氧肌苷 VS ZDV 加 DDI 用于治疗 HIV 感染儿童

• 批准号: 3788651
• 负责人: MARILYN G DOYLE
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3788651
• 关键词: 2'3' dideoxyinosine; AIDS therapy; HIV infections; child (0-11); clinical trials; combination chemotherapy; drug adverse effect; drug screening /evaluation; human subject; human therapy evaluation; neuropsychology; opportunistic infections; oral administration; pediatric AIDS; psychophysiology; zidovudine

This is a multicenter, randomized double blind trial of Zidovudine (ZDV) versus 2',3' dideoxyinosine (ddI) versus a combination of ZDV and ddI in symptomatic HIV-infected children to evaluate the safety, tolerance, and efficacy of the treatment arms. All drugs will be administered orally. Evaluation of response will be based on survival, disease progression, development of opportunistic infections, growth parameters, and neuropsychological function.

这是一项多中心、随机、双盲试验 与2 '，3'双脱氧肌苷（ddI）相比， 有症状的HIV感染儿童，以评估安全性，耐受性， 治疗组的疗效。 所有药物均为口服给药。 缓解评价将基于生存期、疾病进展， 机会性感染的发生，生长参数，和 神经心理功能