ESTROGEN FEEDBACK SIGNAL ON THE GONADOTROPIC, SOMATOTROPIC AND LACTOTROPIC AXES

促性腺激素、促生长激素和催乳激素轴上的雌激素反馈信号

• 批准号: 3787736
• 负责人: JOHANNES D VELDHUIS
• 金额: --
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3787736
• 关键词: drug administration rate /duration; endocrine pharmacology; estradiol; gonadotropins; hormone regulation /control mechanism; human subject; intravenous administration; pharmacokinetics; pituitary gonadal axis; prolactin; secretion; somatotropin

The nature and magnitude of the feedback actions of estradiol on the gonadotropic axis (negative feedback) and the somato- and lactotropic axes (positive feedback) are specified by the time-course of steroid delivery; i.e. pulsatile versus the time-invariant estradiol secretion/infusion.

雌激素对卵巢上皮细胞的反馈作用的性质和程度 促性腺轴（负反馈）和促体细胞和催乳细胞 轴（正反馈）由类固醇的时间过程指定 递送;即脉冲式与时不变雌二醇 分泌/输注。