BENIGN-MALIGNANT LESION DIFFERENTIATION USING FUNCTIONAL ADC-THRESHOLDING

使用功能性 ADC 阈值区分良恶性病变

• 批准号: 8362919
• 负责人: JOHANNES D VELDHUIS
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362919
• 关键词: Annual Reports; Benign; Blood Vessels; Cystic Lesion; Data Set; Diagnosis; Diffusion weighted imaging; Discrimination; Evaluation; Funding; Grant; Health Insurance Portability and Accountability Act; Hospitals; Image; Institutional Review Boards; Lesion; Magnetic Resonance; Magnetic Resonance Imaging; Malignant - descriptor; Maps; National Center for Research Resources; Pathology; Phase; Physiologic pulse; Predisposition; Principal Investigator; Reading; Research; Research Infrastructure; Resources; Source; Technology; United States National Institutes of Health; Visit; Weight; Woman; abstracting; base; breast lesion; cost; interest; malignant breast neoplasm; patient population; radiologist

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Benign-Malignant Lesion Differentiation Using Functional ADC-Thresholding  Allowing Expert Radiologist Interpretation  Versus Conventional Thresholding Based On ADC Cut-Off Values Diffusion-weighted imaging (DWI) may aid in the discrimination of benign from malignant (breast) lesions. Approaches to benefit from the information contained in the DWI dataset have mostly been based on trying to define a cut-off value for the lesion ADC. This may be limiting because of the relatively low SNR, the relatively high variability of lesion ADC - even within one hospital or patient population - and the limited potential of the results to be extrapolated to different field strengths, pulse-sequences or b-values. We used an approach in which the high CNR of DWI and the quantitative information of the ADC are presented to the radiologist in a "functionally-thresholded ADC (ftADC) map" that increases the conspicuity of lesions of interest, much like phase-images are used to increase vascular conspicuity in susceptibility- weighted imaging. Radiologists can "window-level" ftADC-maps at their discretion and diagnose a lesion as "ftADC-bright" without having to choose an ADC-threshold value; Similar to, for example, a cystic lesion being interpreted as "T2-bright" without using T2-cut-off values. We performed a retrospective, HIPAA-compliant, IRB-approved analysis of DW data sets of 103 consecutive women who underwent 1.5T MRI for the evaluation of breast cancer. Conventional ADC-thresholding was compared to ftADC-mapping and to dynamic contrast-enhanced (DCE) MRI, for all pathology-verified lesions. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 利用功能性ADC-抑制鉴别良恶性病变  允许放射科专家解释  与基于ADC截止值的传统采样保持相比 弥散加权成像（DWI）可以帮助区分良性和恶性（乳腺）病变。方法来 从DWI数据集中包含的信息中获益主要是基于尝试定义以下值的截止值 病变ADC。这可能是限制性的，因为相对较低的SNR、病变ADC的相对较高的变异性-甚至 在一家医院或患者人群中-以及将结果外推到不同领域的有限潜力 强度、脉冲序列或b值。我们使用了一种方法，其中DWI的高CNR和定量 ADC的信息在“功能阈值ADC（ftADC）图”中呈现给放射科医师， 感兴趣病变的显著性，很像相位图像用于增加血管敏感性的显著性， 加权成像放射科医生可以自行决定“窗口水平”ftADC图，并将病变诊断为“ftADC亮” 无需选择ADC阈值;类似于，例如，囊性病变被解释为“T2亮” 而不使用T2截止值。我们对下列DW数据集进行了回顾性、符合HIPAA、IRB批准的分析： 103名连续女性接受1.5T MRI评估乳腺癌。传统ADC阈值是 与ftADC标测和动态对比增强（DCE）MRI相比，所有经病理证实的病变。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/ （卢卡斯年度报告和 ISMRM 2011摘要）