EFFECTS OF IMMUNOTOXIC XENOBIOTICS ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES

本研究的目的是检查各种因素对 环境因子对人外周血白细胞的影响 在体外暴露后。 三种环境化学品 将检查污染物，包括重金属（Pb2+和Cd2+）， 多环芳烃（苯并（a）芘）和多氯 联苯（PCBs）。 这些药物都是免疫抑制剂， 动物或当人体细胞暴露于体外时。 总的目的 是利用流式细胞术开发免疫毒性的生物标志物。

The purpose of this study is to examine the effects of various environmental agents on human peripheral blood leukocytes (HPBL) following in vitro exposures. Three chemical classes of environmental pollutants will be examined, including heavy metals (Pb2+ and Cd2+), polycyclic aromatic hydrocarbons (benzo(a)pyrene), and polychlorinated biphenyls (PCBs). These agents are all immunsuppressive when given to animals or when human cells are exposed in vitro. The overall purpose is to develop biomarkers for immunotoxicity using flow cytometry.