Cytokines in milk modulate the development of immune responses in the infant

牛奶中的细胞因子调节婴儿免疫反应的发展

• 批准号: nhmrc : 104844
• 负责人: A/Pr Irmeli Penttila
• 金额: $ 12.6万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytokines-milk-modulate-responses-infant/98556
• 关键词: Cytokines; milk; modulate; development; immune

There is substantial epidemiological evidence that formula fed infants are more susceptible than breast fed infants to auto-immune diseases later in life. However direct evidence is lacking and the mechanism is not understood. We aim to provide direct experimental evidence to test the hypothesis that maternal milk regulates infant immune responses by providing the factors that modulates antigen presentation and priming in the neonatal gut. The significance of the study lies in the absence of these regulatory factors in infant formula. The results will allow more fully informed decisions regarding breast feeding, and may lead to the development of infant formula that modulate immune responses in a manner analogous to natural maternal milk.

有大量流行病学证据表明，配方奶粉喂养的婴儿比母乳喂养的婴儿更容易在以后的生活中患上自身免疫疾病。然而，缺乏直接证据，其机制也不清楚。我们的目标是提供直接的实验证据来检验这一假设，即母乳通过提供调节新生儿肠道中抗原呈递和引发的因子来调节婴儿免疫应答。这项研究的意义在于婴儿配方奶粉中不存在这些调节因素。研究结果将使母乳喂养的决策更加充分，并可能导致婴儿配方奶粉的开发，以类似于天然母乳的方式调节免疫反应。