ANTIBODIES TO HUMAN IFN IN JLP PATIENTS TREATED WITH HUMAN IFN

接受人干扰素治疗的 JLP 患者中的人干扰素抗体

• 批准号: 3792459
• 负责人: J BEKISZ
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3792459
• 关键词: antibody formation; drug interactions; human tissue; immunotherapy; interferons; larynx disorder

Six hundred and sixty serum samples from 135 patients treated with human leukocyte alpha interferon (Hu IFN (Le) (New York Blood Center, Melville, N.Y.) for Juvenile Laryngeal Papillomatosis (J.L.P.) were tested for the presence of neutralizing antibodies to the above-mentioned alpha interferon. Eleven samples were found to contain neutralizing antibodies to alpha interferon from the N.Y.B.C. Ten of these contained neutralizing antibodies to human leukocyte alpha interferon (Alferon; Interferon Sciences, New Brunswick, N.J.) and nine contained neutralizing antibodies to recombinant alpha interferon (Intron A, Schering-Plough, Kenilworth, N.J.). None of the samples were seen to bind to either Alferon or Intron in ELISA assays. Six, however, did bind to Wellferon (Burroughs Wellcome, Beckenham, U.K.) which is a natural lymphoblastoid interferon. Since Wellferon is the starting material used in the purification of interferon components in our laboratory, we intend to determine if the samples which bound to Wellferon will also bind to the purified components.

人血清白蛋白治疗患者660份血清标本 白细胞α干扰素(胡干扰素(Le))(纽约血液中心，梅尔维尔， (纽约州)青少年喉乳头状瘤病(J.L.P.)进行了测试，以检测 存在上述α-抗体的中和抗体 干扰素。11个样本被发现含有中和抗体。 从纽约不列颠哥伦比亚州的阿尔法干扰素。其中10个含有中和 抗人白细胞α干扰素抗体(干扰素 科学，新泽西州新不伦瑞克)九株含有中和抗体 重组α干扰素(内含子A，先灵葆雅，凯尼尔沃思， 新泽西州)。没有一种样品能与Alferon或Intron结合 在酶联免疫吸附试验中。然而，Six确实与Wellferon(Burroughs)绑定 韦尔科姆，英国贝肯汉姆)这是一种天然的淋巴母细胞干扰素。 由于Wellferon是用于提纯 我们实验室的干扰素成分，我们打算确定是否 与Wellferon结合的样本也将结合到纯化的 组件。