ANTIBODIES TO HUMAN IFN IN JLP PATIENTS TREATED WITH HUMAN IFN

来自135名接受人胰岛素治疗的患者的660份血清样品 白细胞α干扰素（HuIFN（Le）（纽约血液中心，梅尔维尔， （纽约）幼年型喉乳头状瘤病（J. L. P.）测定了 存在针对上述α的中和抗体 干扰素 11个样本被发现含有中和抗体 其中10种含有中和性的干扰素 人白细胞α干扰素抗体（Alferon;干扰素 科学，新玩法，新泽西州）9个含有中和抗体 重组α干扰素（Intron A，Schering-Plough，Kenilworth， N.J.）。没有观察到样品与Alferon或Intron结合 在ELISA测定中。 六，然而，没有绑定到Wellferon（巴勒斯 Wellcome，贝克纳姆，英国）这是一种天然的淋巴母细胞干扰素。 由于Wellferon是用于纯化的起始材料， 干扰素成分在我们的实验室，我们打算确定， 与Wellferon结合的样品也将与纯化的 件.

Six hundred and sixty serum samples from 135 patients treated with human leukocyte alpha interferon (Hu IFN (Le) (New York Blood Center, Melville, N.Y.) for Juvenile Laryngeal Papillomatosis (J.L.P.) were tested for the presence of neutralizing antibodies to the above-mentioned alpha interferon. Eleven samples were found to contain neutralizing antibodies to alpha interferon from the N.Y.B.C. Ten of these contained neutralizing antibodies to human leukocyte alpha interferon (Alferon; Interferon Sciences, New Brunswick, N.J.) and nine contained neutralizing antibodies to recombinant alpha interferon (Intron A, Schering-Plough, Kenilworth, N.J.). None of the samples were seen to bind to either Alferon or Intron in ELISA assays. Six, however, did bind to Wellferon (Burroughs Wellcome, Beckenham, U.K.) which is a natural lymphoblastoid interferon. Since Wellferon is the starting material used in the purification of interferon components in our laboratory, we intend to determine if the samples which bound to Wellferon will also bind to the purified components.