ANTIBODIES TO HUMAN IFN IN JPL PATIENTS TREATED WITH HUMAN IFN
ANTIBODIES TO HUMAN IFN IN JPL PATIENTS TREATED WITH HUMAN IFN
批准号:
3748188
负责人:
J BEKISZ
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
adolescence (12-20) antigen antibody reaction biological response modifiers cutaneous papilloma enzyme linked immunosorbent assay human therapy evaluation human tissue hyperplasia immunotherapy interferon alpha larynx disorder larynx neoplasms neoplasm /cancer immunotherapy neutralizing antibody recombinant proteins
中文摘要
用人白细胞α治疗135例患者的血清样本
英文摘要
Serum samples from 135 patients treated with human leukocyte alpha
interferon (Hu IFN (Le) (New York Blood Center, Melville, N.Y. ) for
Juvenile Laryngeal Papillomatosis (J.L.P.) were tested for the presence
of neutralizing antibodies to the above mentioned alpha interferon.
Eleven samples were found to contain neutralizing antibodies to alpha
interferon from the N.Y.B.C. Ten of these contained neutralizing
antibodies to Human leukocyte alpha interferon (Alferon; Interferon
Sciences, New Brunswick, N.J.) and nine contained neutralizing antibodies
to recombinant alpha interferon (Intron A, Schering-Plough, Kenilworth,
N.J.). None of the samples were seen to bind to either Alferon or Intron
in ELISA assays. Six, however, did bind to Wellferon (Burroughs
Wellcome, Beckenham, U.K.) which is a natural lymphoblastoid interferon.
Since we purify IFN-a components in our laboratory using Wellferon as
starting material, we were interested to determine if there was any
binding of the positive samples to our purified components. We found a
low level of binding by three of the samples to an eluate which contains
two of the species. Although the quantity of the aforementioned species
is a limiting factor, we are in the process of running assays which will
show if the antibody present reacts with one or both of these
components.
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会议论文
TRYPTIC DIGESTION OF INTERFERON COMPONENTS
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批准号:3792473
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J BEKISZ
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依托单位:--
ANTIBODIES TO HUMAN IFN IN JLP PATIENTS TREATED WITH HUMAN IFN
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批准号:3792459
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J BEKISZ
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依托单位:--
ANTIBODIES TO HUMAN IFN IN J.L.P. PATIENTS TREATED WITH HUMAN IFN
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批准号:3804736
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J BEKISZ
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依托单位:--
海外基金