CONTINUING STUDIES OF CAT ALLERGY

额外的标准化猫提取物的引入导致了 重新评估这些提取物，以及对提取物的过敏反应。 CAT提取物可含有：(A)毛皮，(B)毛发，(C)头皮屑，(D)浓缩CAT 洗涤、(E)唾液或(F)这些材料的任何混合物，如 产品。目前对猫提取物效力的释放试验是径向的。 免疫扩散试验，测量FEL D 1含量，主要的 猫的过敏原。由于来源材料的不同， 在检测中已检测到蛋白质和非FEL d1变应原水平。 由LAP开发。目前正在开发两种新的检测方法来检测 用RAST法测定标准猫提取液中猫血清的相对含量 抑制试验和荧光相对效力(FRP)试验。等电性 聚焦(IEF)和斑点放射免疫电聚焦(Brief)程序 也被用来评估这些CAT提取物。前期工作 与这些程序表明，可能的重大成分 不同提取物之间可能存在差异。对这些数据的审查仍在进行中 在确定这些发现的意义方面取得进展。

The introduction of additional standardized cat extracts has resulted in a re-evaluation of these extracts, and the allergic response to the extracts. Cat extracts may contain: (a)pelt, (b)hair, (c)dander, (d)concentrated cat wash, (e)saliva, or (f)any mix of these materials as defined in the product. The current release test for potency of cat extracts is a radial immunodiffusion test that measures Fel d 1 content, one of the primary allergens of cat. Due to variability in source material, differences in protein and non-Fel d 1 allergen levels have been detected in assays developed by LAP. Two new assays are being developed to examine the relative quantity of cat serum in standardized cat extracts using the RAST inhibition and a Fluorescent Relative Potency (FRP) tests. Isoelectric Focusing (IEF) and Blotted RadioImmuno ElectroFocusing (BRIEF) procedures are also being utilized to evaluate these cat extracts. Preliminary work with these procedures suggests that possible significant compositional differences may exist between extracts. Review of these data is still in progress to determine the significance of these findings.