SELF REGULATION OF ICAM-1 EXPRESSION IN MELANOMA CELLS

此前已有报道称，两者之间存在相关性 人黑色素瘤细胞转移与ICAM-1的表达 (细胞间黏附分子-1)这些细胞在其表面表达。 几位研究人员提出，这种黏附分子可能在 在这些细胞的迁移过程中扮演了一个角色。我们观察到， ICAM-1在几种黑色素瘤细胞株上的表达 只需在每一面积上种植更多的细胞。初步实验，使用 人类黑色素瘤细胞系A375显示，这些细胞具有结构性 产生一种能够增强ICAM-1表达的因子。此外, 大量实验表明，这种活动并不是由于许多 据报道，由人类肿瘤细胞产生的因子包括 PDGF、碱性成纤维细胞生长因子、转化生长因子-α或转化生长因子-β。旨在隔离和隔离 目前正在确定这一因素。

It has been reported previously that there exists a correlation between the metastasis of human melanoma cells and the amount of ICAM-1 (intercellular adhesion molecule-1) these cells express on their surface. Several investigators have suggested that this adhesion molecule may play a role in the migration of these cells. We have observed that the expression of ICAM-1 on several melanoma cell lines can be enhanced by simply growing more cells per area. Preliminary experiments, using the human melanoma cell line, A375, revealed that these cells constitutively produce a factor which is able to augment ICAM-1 expression. In addition, numerous experiments have shown that this activity is not due to many of the factors which are reportedly produced by human tumor cells such as PDGF, bFGF, TGF-alpha or TGF-beta. Work aimed at isolating and identifying this factor is currently in progress.