SELF REGULATION OF ICAM-1 EXPRESSION IN MELANOMA CELLS

黑色素瘤细胞中 ICAM-1 表达的自我调节

• 批准号: 3804759
• 负责人: D S WEBB
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3804759
• 关键词: cell adhesion molecules; cell communication molecule; cell growth regulation; cell migration; gene expression; growth factor; immunoregulation; melanoma; metastasis; neoplastic cell culture for noncancer research; surface antigens; tumor promoters

It has been reported previously that there exists a correlation between the metastasis of human melanoma cells and the amount of ICAM-1 (intercellular adhesion molecule-1) these cells express on their surface. Several investigators have suggested that this adhesion molecule may play a role in the migration of these cells. We have observed that the expression of ICAM-1 on several melanoma cell lines can be enhanced by simply growing more cells per area. Preliminary experiments, using the human melanoma cell line, A375, revealed that these cells constitutively produce a factor which is able to augment ICAM-1 expression. In addition, numerous experiments have shown that this activity is not due to many of the factors which are reportedly produced by human tumor cells such as PDGF, bFGF, TGF-alpha or TGF-beta. Work aimed at isolating and identifying this factor is currently in progress.

以前有报道说， 人黑色素瘤细胞的转移和ICAM-1的含量 （细胞间粘附分子-1）这些细胞在其表面上表达。 一些研究者认为，这种粘附分子可能在 在这些细胞的迁移中起作用。 我们观察到 ICAM-1在几种黑色素瘤细胞系上的表达可以通过以下方式增强： 简单地在每个区域生长更多的细胞。 初步实验，使用 人黑色素瘤细胞系A375显示，这些细胞组成型 产生能够增加ICAM-1表达的因子。 此外，本发明还提供了一种方法， 许多实验表明，这种活性不是由于许多 据报道由人肿瘤细胞产生的因子， PDGF、bFGF、TGF-α或TGF-β。 旨在隔离和 目前正在查明这一因素。