SELF REGULATION OF ICAM-1 EXPRESSION IN MELANOMA CELLS

黑色素瘤细胞中 ICAM-1 表达的自我调节

• 批准号: 3804759
• 负责人: D S WEBB
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3804759
• 关键词: cell adhesion molecules; cell communication molecule; cell growth regulation; cell migration; gene expression; growth factor; immunoregulation; melanoma; metastasis; neoplastic cell culture for noncancer research; surface antigens; tumor promoters

It has been reported previously that there exists a correlation between the metastasis of human melanoma cells and the amount of ICAM-1 (intercellular adhesion molecule-1) these cells express on their surface. Several investigators have suggested that this adhesion molecule may play a role in the migration of these cells. We have observed that the expression of ICAM-1 on several melanoma cell lines can be enhanced by simply growing more cells per area. Preliminary experiments, using the human melanoma cell line, A375, revealed that these cells constitutively produce a factor which is able to augment ICAM-1 expression. In addition, numerous experiments have shown that this activity is not due to many of the factors which are reportedly produced by human tumor cells such as PDGF, bFGF, TGF-alpha or TGF-beta. Work aimed at isolating and identifying this factor is currently in progress.

此前已有报道称，两者之间存在相关性。 人黑色素瘤细胞的转移与ICAM-1的量 （细胞间粘附分子-1）这些细胞在其表面表达。 一些研究人员认为这种粘附分子可能发挥作用 在这些细胞的迁移中发挥作用。 我们观察到 ICAM-1 在几种黑色素瘤细胞系上的表达可以通过以下方法增强： 只是在每个区域生长更多的细胞。 初步实验，使用 人类黑色素瘤细胞系 A375 揭示了这些细胞组成型 产生能够增强 ICAM-1 表达的因子。 此外， 大量实验表明，这种活动并不是由于许多 据报道，人类肿瘤细胞产生的因子，例如 PDGF、bFGF、TGF-α 或 TGF-β。 旨在隔离和 目前正在确定这一因素。