SELF REGULATION OF ICAM-1 EXPRESSION IN MELANOMA CELLS
SELF REGULATION OF ICAM-1 EXPRESSION IN MELANOMA CELLS
批准号:
3804759
负责人:
D S WEBB
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
以前有报道说,两者之间存在相关性
英文摘要
It has been reported previously that there exists a correlation between
the metastasis of human melanoma cells and the amount of ICAM-1
(intercellular adhesion molecule-1) these cells express on their surface.
Several investigators have suggested that this adhesion molecule may play
a role in the migration of these cells. We have observed that the
expression of ICAM-1 on several melanoma cell lines can be enhanced by
simply growing more cells per area. Preliminary experiments, using the
human melanoma cell line, A375, revealed that these cells constitutively
produce a factor which is able to augment ICAM-1 expression. In addition,
numerous experiments have shown that this activity is not due to many of
the factors which are reportedly produced by human tumor cells such as
PDGF, bFGF, TGF-alpha or TGF-beta. Work aimed at isolating and
identifying this factor is currently in progress.
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REGULATION OF ADHESION MOLECULE EXPRESSION ON HUMAN MONOCYTES BY CYTOKINES
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批准号:3811207
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D S WEBB
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依托单位:--
LFA-3, CD44, AND CD45--PHYSIOLOGIC TRIGGERS OF MONOCYTE TNF AND IL-1 RELEASE
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批准号:3811206
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D S WEBB
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依托单位:--
ENHANCEMENT OF ICAM-1 SENSITIZES TUMOR CELLS TO MONOCYTE-MEDIATED LYSIS
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批准号:3804743
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D S WEBB
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依托单位:--
LFA-3, CD44, AND CD45--PHYSIOLOGIC TRIGGERS OF MONOCYTE TNF AND IL-1 RELEASE
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批准号:3804742
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D S WEBB
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依托单位:--
PRODUCTION OF MONOCYTE COLONY STIMULATING FACTOR BY HUMAN MELANOMA CELLS
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批准号:3804760
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D S WEBB
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依托单位:--
ISOLATION AND IDENTIFICATION OF THE LPS BINDING PROTEINS ON HUMAN MONOCYTES
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批准号:3792488
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D S WEBB
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依托单位:--
INTERLEUKIN 1 RELEASE BY HUMAN MONOCYTES
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批准号:3792489
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D S WEBB
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依托单位:--
ENHANCEMENT OF ICAM-1 SENSITIZES TUMOR CELLS TO MONOCYTE-MEDIATED LYSIS
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批准号:3811208
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D S WEBB
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依托单位:--