ROLE OF CYTOKINES IN ALLERGIC DISORDERS

这项计划是应NIAID的要求而制定的 哮喘和变态反应性疾病合作疾病中心由 加州大学圣地亚哥分校医学院的研究人员具有临床和 过敏性疾病的基础研究。该提案包括一项 教育示范计划和四个基础研究项目 涉及哮喘和其他过敏性疾病患者的细胞。 基础研究侧重于细胞因子在免疫球蛋白E调节和调节中的作用 变态反应性炎症与肥大细胞介质的作用 内皮细胞、呼吸道上皮细胞和角质形成细胞的功能。

This program has been formulated in response to the NIAID request for an Asthma and Allergic Disease Cooperative Disease Center by a team of investigators at UCSD Medical School with expertise in both clinical and basic research of allergic diseases. The proposal consist of an educational and demonstration program and four basic research projects involving cells from patients with asthma and other allergic disorders. The basic research focuses on the role of cytokines in IgE regulation and allergic inflammation and the effects of mast cell mediators on the function of endothelial cells, airway epithelial cells and keratinocytes.