Th9 cells in immediate hypersensitivity
速发型超敏反应中的 Th9 细胞
基本信息
- 批准号:10083170
- 负责人:
- 金额:$ 39.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:Active ImmunizationAcuteAddressAllergensAllergicAllergic DiseaseAllergic inflammationAllergy to peanutsAnaphylaxisAsthmaAttenuatedCell Differentiation processCell physiologyCellsCessation of lifeChronicChronic DiseaseCost of IllnessDataDevelopmentDiseaseGenesGoalsHealthHealth Care CostsHelper-Inducer T-LymphocyteHypersensitivityIL9 geneIgEImmediate hypersensitivityImpairmentInflammationInflammation MediatorsInflammatoryInterleukin-4Interleukin-9InterventionLeadLinkLung InflammationMediatingModelingMusOrganPassive ImmunizationPathway interactionsPatientsPhenotypeProductionProductivityReactionRoleSerumSignal TransductionSkinSymptomsT-LymphocyteTestingTherapeutic InterventionTransgenic OrganismsUnited StatesUrticariaWorkallergic airway inflammationallergic responseasthmatic patientbasecrosslinkcytokinemast cellnew therapeutic targetnovelresponsetranscription factor
项目摘要
PROJECT SUMMARY / ABSTRACT – Th9 cells in immediate hypersensitivity
T helper subsets regulate inflammatory diseases, including the development of allergic lung
inflammation associated with asthma. The development of T helper subsets in controlled by a network of
transcription factors that promote the expression of cytokines and other genes associated with the ability of a T
helper cell to promote disease. This proposal focuses on the most recently identified subset of T helper cells,
Th9 cells that differentiate in response to TGF and IL-4. In our preliminary data we have identified a
requirement for Th9 cells for mast cell accumulation and function in allergic airway inflammation. Interestingly,
we have identified a role for Th9 cells in facilitating immediate hypersensitivity responses. In the two Aims in
this proposal we address basic questions that are critical for understanding Th9-dependent mast cell activity. In
the first aim we will define the requirement for Th9 cells in immediate hypersensitivity using allergen
sensitization and passive transfer models of IgE-dependent mast cell function. In the second Aim we will
determine how Th9 cells regulate mast cell accumulation and activation, and determine which aspect is
required for Th9-dependent mast cell function. Together, these Aims will define new mechanisms involved in
Th9-dependent acute allergen responses. These Aims will elucidate new pathways in acute and chronic
allergic responses and highlight potentially new pathways for intervention.
项目总结/摘要-速发型超敏反应中的Th 9细胞
辅助性T细胞亚群调节炎症性疾病,包括过敏性肺的发展
与哮喘有关的炎症。辅助性T细胞亚群的发育受一个免疫调节网络的控制,
这些转录因子促进细胞因子和其他与T细胞活化能力相关的基因的表达,
辅助细胞促进疾病。这项建议的重点是最近确定的T辅助细胞的子集,
Th 9细胞响应于TGF β 1和IL-4而分化。在我们的初步数据中,
过敏性气道炎症中肥大细胞积累和功能对Th 9细胞的需求有趣的是,
我们已经确定了Th 9细胞在促进速发型超敏反应中的作用。在两个目标中
我们的这个提议解决了对于理解Th 9依赖性肥大细胞活性至关重要的基本问题。在
第一个目的是确定使用过敏原的速发型超敏反应对Th 9细胞的需求
IgE依赖性肥大细胞功能的致敏和被动转移模型。在第二个目标中,
确定Th 9细胞如何调节肥大细胞的积累和激活,并确定哪个方面是
Th 9依赖性肥大细胞功能所必需的。这些目标将共同确定新的机制,
Th 9依赖性急性过敏原反应。这些目标将阐明急性和慢性疾病的新途径。
过敏反应,并强调潜在的新的干预途径。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Transcription Factors in the Development and Pro-Allergic Function of Mast Cells.
- DOI:10.3389/falgy.2021.679121
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Srivastava M;Kaplan MH
- 通讯作者:Kaplan MH
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases.
- DOI:10.3389/fimmu.2018.01212
- 发表时间:2018
- 期刊:
- 影响因子:7.3
- 作者:Imam T;Park S;Kaplan MH;Olson MR
- 通讯作者:Olson MR
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{{ truncateString('MARK H KAPLAN', 18)}}的其他基金
IL-9-dependent interstitial macrophage function in the allergic lung
过敏性肺中 IL-9 依赖性间质巨噬细胞功能
- 批准号:
10741356 - 财政年份:2017
- 资助金额:
$ 39.38万 - 项目类别:
Granzyme A-secreting T cells in allergic inflammation
过敏性炎症中粒酶 A 分泌 T 细胞
- 批准号:
8869766 - 财政年份:2015
- 资助金额:
$ 39.38万 - 项目类别:
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