ACTIVATION OF FVIII BY FXA AND INHIBITION BY TISSUE FACTOR PATHWAY INHIBITOR
FXA 对 FVIII 的激活和组织因子途径抑制剂的抑制
基本信息
- 批准号:3804919
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Bovine factor Xa will cleave factor VIII in at least three regions
resulting in factor VIII that expresses as much as two-fold increased
activity in a one-stage clotting assay. Very small amounts of fXa can
be used such that the rate of cleavage is slow and can be followed for
up to 60 minutes. The cleavage can also be demonstrated by immunoblot
on which the disappearance of some fVIII bands and the appearance of the
corresponding cleavage fragments can be shown. Tissue factor pathway
inhibitor (TEPI) is known to bind and inhibit fXa. This complex then
binds to tissue factor/factor VIIa and inhibits the formation of more
Xa. We are studying the ability of TFPI to also inhibit the Xa-induced
cleavage of factor VIII.
牛因子Xa将在至少三个区域分裂因子VIII
项目成果
期刊论文数量(0)
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W FRICKE其他文献
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{{ truncateString('W FRICKE', 18)}}的其他基金
EPITOPE MAPPING OF FACTOR VIII AND VON WILLEBRAND FACTOR
因子 VIII 和冯·维勒布兰德因子的表位作图
- 批准号:
3770445 - 财政年份:
- 资助金额:
-- - 项目类别:
CHARACTERIZATION OF THE FACTOR VIII IN FACTOR VIII CONCENTRATES
因子 VIII 浓缩物中因子 VIII 的表征
- 批准号:
3792653 - 财政年份:
- 资助金额:
-- - 项目类别:
HIV INFECTION DUE TO CLOTTING FACTOR CONCENTRATES--RESULTS OF THE SSP
浓缩凝血因子引起的 HIV 感染——SSP 结果
- 批准号:
3792655 - 财政年份:
- 资助金额:
-- - 项目类别:
COMPARISON OF THE CHROMOGENIC AND ONE-STAGE ASSAYS FOR FACTOR IX
因子 IX 显色法和一阶段法的比较
- 批准号:
3804918 - 财政年份:
- 资助金额:
-- - 项目类别: