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EPITOPE MAPPING OF ANTIBODIES TO VON WILLEBRAND FACTOR

EPITOPE MAPPING OF ANTIBODIES TO VON WILLEBRAND FACTOR
血管性血友病因子抗体的表位作图
批准号:
3792657
负责人:
W FRICKE
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
两名患有血管性血友病因子抗体的患者的血浆
英文摘要
Plasma from two patients with antibodies to von Willebrand factor are being studied to identify the epitopes on von Willebrand factor that are recognized by the antibodies. The general approach has been to enzymatically cleave vWf and then immunoprecipitate the resulting fragments using patient immunoglobulin covalently coupled to protein A - Sepharose beads. Following digestion of vWf by thrombin, numerous fragments ranging in size from about 176 kD to 40 kD are generated. Preliminary experiments using a burro polyclonal antibody have not been sucessful in immunoprecipitating any vWf fragments. It is unclear as to why, but possible explanations include destruction of the epitopes by digestion and insufficient protein to be detected by immunoblotting. Plasma from two patients with antibodies to vWf will be used in these studies when it is clear that the vWf fragments can be immunoprecipitated by this method.
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会议论文
ACTIVATION OF FVIII BY FXA AND INHIBITION BY TISSUE FACTOR PATHWAY INHIBITOR
EPITOPE MAPPING OF ANTIBODIES TO FACTOR VIII
EPITOPE MAPPING OF FACTOR VIII AND VON WILLEBRAND FACTOR
  • 批准号:
    3770445
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    W FRICKE
  • 依托单位:
    --
EFFECT OF FACTOR XIA ON FACTOR VIII
  • 批准号:
    3770444
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    W FRICKE
  • 依托单位:
    --
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