浓缩凝血因子引起的 HIV 感染——SSP 结果-猫眼课题宝

浓缩凝血因子引起的 HIV 感染——SSP 结果

批准号：

3792655

负责人：

W FRICKE

金额：

$0.0万

依托单位：

CENTER BIOLOGICS EVALUATION RESEARCH HEMATOLOGY

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3792655

关键词：

HIV infections blood transfusion clotting factor communicable disease transmission data collection disease /disorder proneness /risk drug quality /standard epidemiology health surveys hemophilia As human immunodeficiency virus human subject interview questionnaires

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英文摘要

Between 1987 and the present, the Seroconversion Surveillance Project has provided the means to monitor the risk of transmission of human immunodeficiency virus (HIV) by clotting factor concentrates. One hundred and thirty-one hemophilia treatment centers in the United States are regularly contacted and data on HIV testing of patients collected. To date, 4366 (46.0%) of 9496 patients have been reported to be seropositive, and thirty-seven new seroconversions identified. Nine of these have met the CDC criteria for seroconversion while taking factor concentrate. None of the nine seroconversions were due to concentrates that had been treated to inactivate viruses and made from plasma that had been tested for HIV antibody. Our results indicate that there is a high prevalence of seropositivity in affected patient groups, but that the risk of HIV infection from currently available clotting factor concentrates is extremely low.

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