STUDY OF SURGERY AND PHOTODYNAMIC THERAPY FOR INTRAPERITONEAL MALIGNANCIES

弥漫性种植于腹膜腔的肿瘤患者有一种 常规治疗预后较差。卵巢癌是一种肿瘤 表现为扩散到腹膜的晚期疾病 在23,000名卵巢发育的女性中，大约70%的人出现了卵巢表面 美国每年都有癌症。中国的无病生存 这些患者在5年内接受常规治疗的比例不到10%， 它包括最初的整容手术，然后是多智能体 化疗。我们已经能够对一个类似的卵巢肿瘤进行绝育 在使用腹膜内光动力疗法的小鼠模型中， 即定位于肿瘤内并可被激活的光敏剂 光可以摧毁癌细胞。我们一直有兴趣将 将这一策略引入卵巢癌患者的管理和 因此启动了这一第一阶段试验。

The patients with tumors diffusely seeding the peritoneal cavity have a poor prognosis with conventional treatment. Ovarian cancer is one tumor which presents with advanced disease diffusely involving the peritoneal surface in approximately 70% of the 23,000 women who develop ovarian cancer annually in the United States. The disease free survival in these patients at 5 years is less than 10% with conventional management, which involves initial debulking surgery followed by multi-agent chemotherapy. We have been able to sterilize an ovarian tumor similar to this in a mouse model using intraperitoneal photodynamic therapy, i.e. a photosensitizer which localizes in tumor and can be activated by light to destroy cancer cells. We have been interested in incorporating this strategy into the management of patients with ovarian cancer and have thus initiated this Phase I trial.