PHASE I STUDY OF PHOTODYNAMIC THERAPY FOR SURFACE MALIGNANCIES

放射肿瘤科已将15名患者送入 这项关于光动力疗法的研究。治疗方案 包括静脉注射光敏蛋白II 制备血卟啉衍生物，然后 将光线传送到受影响的区域。光线直射到 利用光纤耦合到氩泵浦的染料激光治疗肿瘤。 在可能的情况下，激光多普勒血流测量已经 对患者治疗前后进行对比观察。15名病人 到目前为止都被写入了议定书。相关毒性 治疗包括皮肤光敏，其中一种 病人手臂上出现一度晒伤 药物输注后78天暴露在阳光下。二 胸壁广泛复发乳腺癌患者的临床分析 治疗区域出现一过性不适，需要 止痛药。在10名复发性疾病患者中 涉及皮肤，已经在一次中获得了完全反应 患有癌症和宫颈癌的患者，一名乳腺癌患者， 还有一名皮肤淋巴瘤患者。污水再曝气 两名肺衰竭患者已实现肺功能 继发于主干支气管肿瘤梗阻性病变 继支气管镜检查后移动坏死性肿瘤；第三例 在编写本报告时，患者正在等待治疗。灯 探查时进入腹膜腔的分娩 一名患者使用特殊的开腹手术完成了剖腹手术 设计的光扩散棒和脂内稀释液 在手术时注入到腹膜腔。 用无菌光电二极管测量室内光线分布 已经做好了腹膜腔。初步分析了我国目前存在的主要问题。 数据将表明，光有显著的衰减 根据目前的血红蛋白，这是一个需要解决的问题，如果 向腹膜表面提供足够的光线将是 以这种方式实现。

The Radiation Oncology Branch has entered fifteen patients onto this study of photodynamic therapy. The treatment protocol involves the intravenous administration of the Photophrin II preparation of the hematoporphyrin derivative, followed by delivery of light to the affected area. Light is directed at the tumor using optical fibers coupled to an argon pumped dye laser. When possible, laser Doppler blood flow measurements have been made on patients before and after treatment. Fifteen patients have been entered onto the protocol to date. Toxicity associated with treatment includes cutaneous photosensitivity, with one patient developing a first degree sunburn on his arms upon exposure to bright sunlight 78 days after drug infusion. Two patients with extensive recurrent breast cancer on the chest wall developed transient discomfort in the treatment area requiring narcotics for pain control. In 10 patients with recurrent disease involving the skin, complete responses have been obtained in one patient with had and neck cancer, one patient with breast cancer, and one patient with cutaneous lymphoma. Re-aeration of the lung has been achieved in two patients with lung collapse secondary to obstructing tumor in the main stem bronchus following clean up bronchoscopy to move necrotic tumor; a third patient is awaiting treatment at the time of this report. Light delivery into the peritoneal cavity at the time of exploratory laparotomy has been achieved in one patient using a specially designed light diffusing rod and a dilute solution of intralipid instilled into the peritoneal cavity at the time of surgery. Measurements of light distribution using sterile photodiodes in the abdominal cavity have been made. Preliminary analysis of the data would indicate that there is significant attenuation of light by hemoglobin present, an issue which will need to be addressed if adequate light delivery to the peritoneal surface is going to be achieved in this manner.