STUDY OF SURGERY AND PHOTODYNAMIC THERAPY FOR INTRAPERITONEAL MALIGNANCIES

肿瘤弥漫性种植于腹膜腔的患者， 常规治疗预后差。卵巢癌是一种 其表现为弥漫性累及腹膜的晚期疾病 在23，000名患有卵巢癌的女性中， 每年在美国。这些患者的无病生存率 在5年内，传统管理的成本低于10%， 额外的减瘤手术，然后进行多药化疗。我们有 能够在小鼠模型中消灭类似的卵巢肿瘤 使用腹膜内光动力疗法，即光敏剂， 定位于肿瘤中，并且可以被光激活以破坏癌细胞。 我们有兴趣将这一战略纳入 卵巢癌患者，并因此启动了这项I期试验。

The patients with tumors diffusely seeding the peritoneal cavity have a poor prognosis with conventional treatment. Ovarian cancer is one tumor which presents with advanced disease diffusely involving the peritoneal surface in approximately 70% of the 23,000 women who have ovarian cancer annually in the United States. The disease free survival in these patients at 5 years is less than 1 0% with conventional management, which involves additional debulking surgery followed by multi-agent chemotherapy. We have been able to sterilize an ovarian tumor similar to this in a mouse model using intraperitoneal photodynamic therapy, i.e. a photosensitizer which localizes in tumor and can be activated by light to destroy cancer cells. We are interested in incorporating this strategy into the management of patients with ovarian cancer and have thus initiated this Phase I trial.