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NOVEL METALLOPROTEINASE INHIBITORS--ROLE IN TUMOR INVASION AND METASTASIS

NOVEL METALLOPROTEINASE INHIBITORS--ROLE IN TUMOR INVASION AND METASTASIS
新型金属蛋白酶抑制剂——在肿瘤侵袭和转移中的作用
批准号：
3813434
负责人：
W G STETLER-STEVENSON
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3813434
关键词：
binding proteins collagenase complementary DNA cysteine enzyme substrate genetic transcription human tissue melanoma metalloenzyme metastasis molecular cloning neoplasm /cancer invasiveness neoplastic cell oncoproteins protease inhibitor stoichiometry zymogens

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中文摘要
翻译
我们分离并表征了一种新分子的完整一级结构
英文摘要
We have isolated and characterized the complete primary structure of a new member of the tissue inhibitor of metalloproteinase family (TIMP family) which we refer to as TIMP-2. TIMP-2 binds specifically to the latent form of the 72 kDa type IV collagenase. Inhibition of the activated enzyme occurs with 1:1 molar stoichiometry. TIMP-2 contains 12 cysteine residues, the positions of which are highly conserved when compared with the primary structure of TIMP-1. We have obtained a 1.0 kB cDNA clone which encodes for the pro-TIMP-2. This clone encodes for a 194 amino acid mature TIMP-2 molecule and a 26 amino acid signal peptide. Recent studies have focused on the production of recombinant TIMP-2 and transcriptional regulation of the TIMP-2 transcript levels.
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NOVEL METALLOPROTEINASE INHIBITORS--ROLE IN TUMOR INVASION AND METASTASIS
ROLE OF COLLAGENOLYTIC METALLOPROTEINASES IN METASTASES
ROLE OF COLLAGENOLYTIC METALLOPROTEINASES IN METASTASES
NOVEL METALLOPROTEINASE INHIBITORS--ROLE IN TUMOR INVASION AND METASTASIS
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