REGULATION OF TRANSCRIPTION IN SV40 AND ADENOVIRUS
REGULATION OF TRANSCRIPTION IN SV40 AND ADENOVIRUS
批准号:
3874660
负责人:
J BRADY
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Adenoviridae DNA binding protein Polyomavirus hominis 2 aminoacid complementary DNA gel electrophoresis gene expression gene induction /repression genetic enhancer element genetic manipulation genetic promoter element genetic transcription mutant neoplasm /cancer genetics nucleic acid probes plasmids protein sequence simian virus 40 transcription factor transfection viral carcinogenesis virus DNA virus antigen virus genetics virus infection mechanism virus protein
中文摘要
肿瘤病毒DNA的转化区。SV40和JCV,以及
英文摘要
The transforming region of the DNA tumor viruses. SV40 and JCV, and
adenovirus regulates transcription of viral and cellular genes. The
purpose of these studies is to investigate the mechanism by which the T/t
antigen(s) and E1A proteins modulate transcription and its relationship to
cellular transformation. In adenovirus, The EIIA upstream sequences which
contain the binding sites for proteins ATF and EIIF act as an enhancer and
can be trans-activated by both EIA and SV40 T/t antigens. Specific
mutation of either the ATF and EIIF binding sites inhibited the EIIA
enhancer 200-fold. Analysis of insertion mutation suggests that the spatial
alignment of the upstream ATF and EIIF binding sites with respect to the
downstream EIIF binding site on the DNA helix is important. Consistent with
previous findings, using gel shift analysis we demonstrate that the binding
activity of EIIF is increased following wild-type adenovirus infection. In
contrast, using identical gel shift conditions, the binding activity of ATF
is decreased by viral infection . Since ATF is actually a family of closely
related transcription factors, studies are in progress to look at
differential regulation in response to adenovirus infection.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
HTLV-1 TAX1 AS AN EXTRACELLULAR CYTOKINE
-
批准号:2468441
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
INTERACTION OF HTLV-1 TAX WITH CELLULAR REGULATORY PROTEINS
-
批准号:6100851
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
REGULATION OF VIRAL AND CELLULAR GENE EXPRESSON
-
批准号:6100779
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
TRANSCRIPTION ANALYSIS OF THE JC VIRUS ENHANCER
-
批准号:3916808
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
TRANSCRIPTION ANALYSIS OF THE JC VIRUS ENHANCER
-
批准号:3874659
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
SJOGREN'S SYNDROME IN HTLV-1 TRANSGENIC MICE
-
批准号:3896382
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
REGULATION OF VIRAL AND CELLULAR GENE EXPRESSON
-
批准号:2468429
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
INDUCTION OF NF-KB AFTER EXPOSURE OF LYMPHOID CELLS TO SOLUBLE TAX1
-
批准号:3838474
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
REGULATION OF GENE EXPRESSION
-
批准号:3874634
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
TRANSCRIPTION ANALYSIS OF THE SV40 EARLY AND LATE PROMOTER
-
批准号:3963502
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
HIV TAT GENE AND TRANSCRIPTIONAL ACTIVATION
-
批准号:5201571
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
REGULATION OF VIRAL AND CELLULAR GENE EXPRESSON
-
批准号:6160879
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
HIV TAT GENE AND TRANSCRIPTIONAL ACTIVATION
-
批准号:3774938
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
TRANSFORMATION BY HUMAN CMV
-
批准号:3874751
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
ENHANCER ELEMENTS IN B-LYMPHOCYTES AND T-LYMPHOCYTES
-
批准号:3939687
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
STUDIES ON THE ACTIVATED FORM OF THE HUMAN PROTO-ONCOGENE, C-HA-RAS
-
批准号:3939670
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
TRANSCRIPTION ANALYSIS OF THE SV40 EARLY AND LATE PROMOTER
-
批准号:3939684
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
HIV TAT GENE AND TRANSCRIPTIONAL ACTIVATION
-
批准号:2468444
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
REGULATION OF SV40 GENE EXPRESSION
-
批准号:3939643
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
REGULATION OF SV40 GENE EXPRESSION
-
批准号:3916769
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:J BRADY
-
依托单位:
海外基金