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MOLECULAR STRUCTURE OF HAV--GENOME SEQUENCE AND ORGANIZATION

MOLECULAR STRUCTURE OF HAV--GENOME SEQUENCE AND ORGANIZATION
甲型肝炎病毒的分子结构--基因组序列和组织
批准号：
3818222
负责人：
J I COHEN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3818222
关键词：
Hepatovirus attenuated microorganism complementary DNA gene deletion mutation genetic mapping genetic translation genome molecular cloning nucleic acid sequence protein sequence tissue /cell culture virus RNA virus envelope virus genetics virus protein

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中文摘要
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英文摘要
RNAs transcribed from the cDNA clones of wild-type, cell culture adapted hepatitis A virus, or mutants constructed from these clones are being translated in vitro to define the parameters affecting the efficiency of translation. Deletion mutants have been constructed to answer the question of whether hepatitis A viability requires an intact VP4 gene or whether myristylation of VP4 is important.
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