Deciphering the role of DNA methylation in the regulation of alternative splicing

解读 DNA 甲基化在可变剪接调节中的作用

• 批准号: nhmrc : GNT1129901
• 负责人: Dr Justin Wong
• 金额: $ 86.55万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-role-dna-alternative-splicing/1347784
• 关键词: Deciphering; role; DNA; methylation; regulation

When a gene is turned on, the messenger RNA must be correctly processed to generate functional proteins. This ‘splicing’ process is essential for normal cellular activity, and is disrupted in many human diseases. We have discovered that an epigenetic modification, DNA methylation (mC), may control splicing. This project will investigate how mC influences splicing and use new epigenome-editing tools to control it, in order to ultimately understand and treat diseases involving aberrant splicing.

当基因被打开时，信使RNA必须被正确加工以产生功能性蛋白质。这种“剪接”过程对于正常细胞活动至关重要，但在许多人类疾病中会被破坏。我们发现表观遗传修饰 DNA 甲基化 (mC) 可能控制剪接。该项目将研究mC如何影响剪接，并使用新的表观基因组编辑工具来控制它，以最终了解和治疗涉及异常剪接的疾病。