Investigating the role of aberrant splicing (intron retention) in acute myeloid leukaemia

研究异常剪接（内含子保留）在急性髓系白血病中的作用

• 批准号: nhmrc : GNT1128175
• 负责人: Dr Justin Wong
• 金额: $ 113.57万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-role-aberrant-myeloid-leukaemia/1347671
• 关键词: Investigating; role; aberrant; splicing; intron

In 2013, we made a breakthrough discovery that certain parts of genes, previously considered “Junk DNA”, are actually carrying signals to control the amount of proteins produced in cells. Our preliminary work now suggests these signals controlling protein levels can be faulty in cancers. Here, we wish to determine whether these faulty signals could cause a deadly blood cancer called acute myeloid leukaemia (AML). We aim to decipher previously unknown causes of AML that will spur novel therapies.

2013年，我们取得了突破性的发现，以前被认为是“垃圾DNA”的基因的某些部分实际上携带着控制细胞中产生的蛋白质数量的信号。我们的初步工作现在表明，这些控制蛋白质水平的信号在癌症中可能是错误的。在这里，我们希望确定这些错误的信号是否会导致一种称为急性骨髓性白血病（AML）的致命血癌。我们的目标是破译以前未知的AML原因，这将刺激新的治疗方法。