Investigating widespread regulation of gene expression through intron retention

通过内含子保留研究基因表达的广泛调控

• 批准号: nhmrc : 1080530
• 负责人: Dr Justin Wong
• 金额: $ 24.21万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-widespread-regulation-intron-retention/518756
• 关键词: Investigating; widespread; regulation; gene; expression

We recently discovered a hidden type of gene regulation that appears to be altered in diverse cancers including leukaemia, melanoma and colon cancer. We will explore this widely relevant mechanism using molecular and computational tools. We created the only computer program able to detect this type of regulation and will now share our discovery with cancer scientists through cloud computing technology.

我们最近发现了一种隐藏的基因调控类型，它似乎在多种癌症中发生了改变，包括白血病、黑色素瘤和结肠癌。我们将使用分子和计算工具来探索这种广泛相关的机制。我们创建了唯一一个能够检测这种调节的计算机程序，现在将通过云计算技术与癌症科学家分享我们的发现。