MONOCLONAL ANTIBODIES DEFINE CARCINOMA ASSOCIATED AND DIFFERENTIATION ANTIGENS

单克隆抗体定义癌相关抗原和分化抗原

• 批准号: 3939256
• 负责人: J SCHLOM
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939256
• 关键词: adenocarcinoma; antibody formation; breast neoplasms; carcinoembryonal antigen; carcinoma; cell differentiation; cellular oncology; flow cytometry; histochemistry /cytochemistry; human tissue; hybridomas; immunoglobulins; metastasis; monoclonal antibody; neoplasm /cancer immunology; radioimmunoassay; tumor antigens

These studies involve the generation and utilization of monoclonal antibodies (MAbs) to identify and characterize human carcinoma associated antigens and differentiation antigens of mammary and colonic epithelium. These MAbs are being used to better understand the cell biology and pathogenesis of human carcinomas, and to provide reagents for use in several aspects of the management of human carcinomas. These include: detection of occult tumor cells; further defining the degree of differentiation of "normal", dysplastic, and carcinoma cell populations; serum antigens assays; and radiolocalization of primary and metastatic carcinoma lesions in situ (and potentially therapy) using radiolabeled monoclonal immunoglobulins and fragments. These studies are divided into four areas of investigation: (I) The generation and characterization of an MAb that defines a novel tumor associated antigen (TAG-72); (II) The development and characterization of MAbs to a repertoire of epitopes on carcinoembryonic antigen (CEA) which are differentially expressed among carcinoma cell populations; (III) The generation and characterization of MAbs to proteins associated with metastatic cell populations, and (IV) The definition and characterization of breast and colon differentiation antigens.

这些研究涉及单克隆抗体的产生和利用 用于识别和表征人类癌症的抗体 (MAb) 乳腺相关抗原和分化抗原 结肠上皮。 这些单克隆抗体被用来更好地 了解人类的细胞生物学和发病机制 癌症，并提供用于多个方面的试剂 人类癌症的治疗。 其中包括：检测 隐匿性肿瘤细胞；进一步定义程度 “正常”细胞、发育异常细胞和癌细胞的分化 人口；血清抗原测定；和无线电定位 原发性和转移性癌原位病变（并且可能 疗法）使用放射性标记的单克隆免疫球蛋白和 碎片。 这些研究分为四个领域 研究：(I) MAb 的产生和表征 定义了一种新型肿瘤相关抗原（TAG-72）； （二） MAb 的开发和表征 癌胚抗原（CEA）上的表位是 癌细胞群体之间差异表达； （三） 蛋白质单克隆抗体的生成和表征 与转移细胞群相关，以及 (IV) 乳腺和结肠分化的定义和特征 抗原。