PROGRAM PROJECT IN TRANSPLANTATION BIOLOGY

移植生物学计划项目

• 批准号: 3091825
• 负责人: EMIL Raphael UNANUE
• 金额: $ 52.21万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3091825
• 关键词: histocompatibility antigens; lymphokines; monoclonal antibody; transplantation

A major theme of this program project is the study of accessory cell function required for the stimulation of T helper cells. The two functions that are investigated are the expression and role of two key molecules: interleukin-1 and the class II histocompatibility molecules, or Ia molecules. Two of the projects deal with basic issues concerning some of the regulatory mechanisms that lead to IL-1 and Ia production by antigen presenting cells. Attempts are described to modulate Ia expression mainly by the use of by antibodies to interferon- gamma. The effects of this manipulation in the transplantation of allogeneic tissues is critically analyzed with a number of tissues. One of our objectives is to integrate the activity of basic immunobiologists with transplantation surgeons by creating a program where both activities are deeply interrelated for the benefit of both groups.

该项目的一个主要主题是研究附件 T辅助细胞的刺激所需的细胞功能。 的 研究的两个功能是表达和作用 两个关键分子：白细胞介素-1和II类 组织相容性分子或Ia分子。 两 项目涉及一些监管方面的基本问题， 导致抗原产生IL-1和Ia的机制 递呈细胞。 描述了调节Ia的尝试， 主要通过使用干扰素抗体来表达- γ的 这种操作在移植中的作用 同种异体组织用许多组织进行严格分析。 我们的目标之一是整合基本的活动， 免疫生物学家与移植外科医生通过创建一个 这两项活动是密切相关的计划， 两个群体的利益。