STUDIES IN AUTOLOGOUS BONE MARROW TRANSPLANTATION

自体骨髓移植的研究

• 批准号: 3093021
• 负责人: KAREL A DICKE
• 金额: $ 101.31万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-01-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3093021
• 关键词: autologous transplantation; bone marrow transplantation; neoplasm /cancer therapy

This grant addresses the role of autologous bone marrow transplantation in acute leukemia, myeloma and diffuse large cell lymphoma when combined with high-dose chemotherapy and total body irradiation. As these are bone marrow based diseases, the question of purging to remove malignant cells before transplantation is evident. Two new separation procedures have been developed, in vitro immunocolloid separation and pharmacological tumor cell reduction. We propose to study the effect of the separation technique on hematopoietic reconstruction capacity and the efficacy of each separation as measured by time to tumor recurrence. Detection systems for leukemic cells have been developed using molecular probes and will be applied for monitoring bone marrow for leukemic cell contamination according to method of purging. Well defined tumor markers will be employed in transplants in myeloma.

这笔赠款解决了自体骨髓的作用 急性白血病、骨髓瘤和弥漫性大细胞移植 淋巴瘤与大剂量化疗和总化疗相结合 身体照射。 由于这些是基于骨髓的疾病， 之前清除以去除恶性细胞的问题 移植效果明显。 两个新的分离程序 已开发出体外免疫胶体分离和 药理肿瘤细胞减少。 我们建议研究 分离技术对造血的影响 重建能力和每次分离的功效 通过肿瘤复发的时间来衡量。 检测系统 白血病细胞已使用分子探针开发出来 将用于监测骨髓中的白血病细胞 根据净化方法确定污染情况。 明确定义 肿瘤标志物将用于骨髓瘤移植。