Deciphering how TCR affinity regulates CD4 T cell help in immunity and autoimmunity

解读 TCR 亲和力如何调节 CD4 T 细胞有助于免疫和自身免疫

• 批准号: nhmrc : 1146677
• 负责人: A/Pr Carl Feng
• 金额: $ 56.74万
• 依托单位: Centenary Institute of Cancer Medicine and Cell Biology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-tcr-affinity-immunity-autoimmunity/1320712
• 关键词: Deciphering; how; TCR; affinity; regulates

Immune responses require the coordinated interaction and cross-talk between two types of white blood cells known as CD4 and CD8 T cells. A dysregulated interaction between these cells could be the cause of autoimmune and persistent infections by pathogens leading to chronic diseases. The aim of this proposal is to provide a deeper understanding of CD4/CD8 T cell interactions to improve immune outcomes in many chronic diseases in which interaction between these two immune cells is critical.

免疫反应需要两种类型的白细胞之间的协调相互作用和相互作用，即CD_4和CD_8 T细胞。这些细胞之间的失调相互作用可能是自身免疫和病原体持续感染导致慢性病的原因。这项建议的目的是为了更深入地了解CD4/CD8T细胞之间的相互作用，以改善许多慢性疾病的免疫结果，在这些疾病中，这两种免疫细胞之间的相互作用是至关重要的。