Dissecting in vivo cellular responses to interferons in pathogen-infected hosts

剖析病原体感染宿主体内细胞对干扰素的反应

• 批准号: nhmrc : 1051742
• 负责人: A/Pr Carl Feng
• 金额: $ 31.99万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-vivo-cellular-infected-hosts/112234
• 关键词: Dissecting; vivo; cellular; responses; interferons

Tuberculosis (TB) is caused by virulent bacterium Mycobacterium tuberculosis and is a leading cause of death worldwide. Mechanisms underlying host resistance to the pathogen are poorly understood. Using a novel reporter mouse, the function of interferons in Mtb infection will be defined in vivo by tracking the cytokine-responsive cells. This will increase our understanding of the effects of these important cytokines in vivo, and could provide new candidate biomarkers for TB diagnosis.

结核病是由毒力强的结核分枝杆菌引起的，是世界范围内死亡的主要原因。宿主对病原体的抗性机制尚不清楚。利用一种新的报告小鼠，干扰素在结核分枝杆菌感染中的功能将通过跟踪细胞因子应答细胞来确定。这将增加我们对这些重要细胞因子在体内作用的理解，并可能为结核病诊断提供新的候选生物标志物。