MODULATION OF MYELOID TUMOR CELL GROWTH IN VITRO BY ESTROGEN/PROGESTERONE ANALOGS
MODULATION OF MYELOID TUMOR CELL GROWTH IN VITRO BY ESTROGEN/PROGESTERONE ANALOGS
批准号:
3838079
负责人:
L M NECKERS
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
骨髓性白血病已被证明是特别没有反应,
糖皮质激素治疗,一种在治疗中非常有用的方案,
治疗T和B细胞白血病。我们已经研究了体外
几种骨髓肿瘤细胞系,包括HL 60和U937,
各种性类固醇,包括雌二醇,己烯雌酚(DES),
孕酮和睾酮。 所有测试的细胞系都被证明被杀死
雌二醇、己烯雌酚和孕酮的含量范围为10- 100 μ M。 DES
被证明是最有效的。细胞死亡的方法似乎包括
细胞质肿胀和细胞核挤出,伴有DNA
降解 对氢化可的松和地塞米松敏感的白血病,
如T和B细胞白血病,也对DES非常敏感,
雌二醇和孕酮。 发现所有检测的细胞系均为
雌二醇受体(DES共有),但没有雌二醇受体。
可检测到孕酮。药物有效性体内研究
针对无胸腺小鼠中骨髓肿瘤异种移植物生长的研究正在进行中。
英文摘要
Myeloid leukemias have proven to be particularly unresponsive to
glucocorticoid therapy, a regimen shown to be quite useful in the
treatment of T and B cell leukemias.We have investigated the in vitro
sensitivity of several myeloid tumor cell lines, including HL60 and U937,
to various sex steroids, including estradiol, diethylstilbestrol (DES),
progesterone and testosterone. All cell lines tested proved to be killed
by amounts of estradiol, DES and progesterone ranging from 10-100uM. DES
proved the most effective. The method of cell death appears to involve
cytoplasmic swelling and extrusion of nuclei, accompanied by DNA
degradation. Leukemias sensitive to hydrocortisone and dexamethasone,
such as T and B cell leukemias, were also quite sensitive to DES,
estradiol and progesterone. All cell lines tested were found to posses
receptors for estradiol (which are shared by DES), but no receptors for
progesterone could be detected. in vivo studies of drug effectiveness
against myeloid tumor xenograph growth in athymic mice are underway.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
MODULATION OF CELL GROWTH BY ANTISENSE AND ANTIGENE REAGENTS
-
批准号:5201271
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
REGULATION OF CELL GROWTH BY TRANSFERRIN RECEPTORS
-
批准号:3962905
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
ANALYSIS OF P53 IN TUMOR CELL RESPONSE TO HYPOXIA
-
批准号:6123754
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
MODULATION OF CELL GROWTH BY ANTISENSE AND ANTIGENE REAGENTS
-
批准号:6123657
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
MODULATION OF MYELOID TUMOR CELL GROWTH IN VITRO BY ESTROGEN/PROGESTERONE ANALOGS
-
批准号:3752351
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
INHIBITION OF N-MYC EXPRESSION IN NEUROBLASTOMA CELL LINES
-
批准号:3874465
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
ANALYSIS OF P53 IN TUMOR CELL RESPONSE TO HYPOXIA
-
批准号:6163397
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
MODULATION OF CELL GROWTH BY ANTISENSE AND ANTIGENE REAGENTS
-
批准号:2464446
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
MODULATION OF CELL GROWTH BY ANTISENSE AND ANTIGENE REAGENTS
-
批准号:3752349
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
MODULATION OF CELL GROWTH BY ANTISENSE AND ANTIGENE REAGENTS
-
批准号:6163275
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
REGULATION OF LYMPHOCYTE ACTIVATION AND PROLIFERATION
-
批准号:3939201
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
LAK CELL LEUKEMIAS
-
批准号:3963084
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
MECHANISM OF TAXOL INDUCED APOPTOSIS
-
批准号:2464562
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
ANALYSES OF AUTOCRINE GROWTH OF FOLLICULAR LYMPHOMA CELLS IN VITRO
-
批准号:5201272
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
MODULATION OF MYELOID TUMOR CELL GROWTH IN VITRO BY ESTROGEN AND PROGESTERONE
-
批准号:5201273
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
MOLECULAR BIOLOGY OF TRANSFERRIN RECEPTOR EXPRESSION
-
批准号:3963081
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
EVALUATION OF CYTOTOXICITY OF ANSAMYCINS TO DEFINED CELL LINES
-
批准号:3838075
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
MODULATION OF CELL GROWTH BY ANTISENSE AND ANTIGENE REAGENTS
-
批准号:3838076
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
REGULATION OF CELL GROWTH BY TRANSFERRIN RECEPTORS
-
批准号:4691710
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
DIFFERENTIATION OF IMMATURE T CELL NEOPLASMS BY INTERLEUKIN-2
-
批准号:3939357
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:L M NECKERS
-
依托单位:
海外基金