LAK CELL LEUKEMIAS

LAK细胞白血病

• 批准号: 3963084
• 负责人: L M NECKERS
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3963084
• 关键词: gene expression; interleukin 2; leukemia; leukocyte activation /transformation; lymphoma; myeloid stem cell; tissue /cell culture

We have studied 3 cases of leukemias with mixed phenotype and 2 lymphoblastic lymphomas trying to further characterize them. These cells respond to treatment with IL-2 as do normal LAK cells, in that they develop the ability to kill tumor cells. Their phenotype changes to resemble that of the mature LAK cell. Using these cases, we propose that the normal LAK progenitor cell is a T/myeloid stem cell which can be differentiated by IL-2 to become a mature LAK cell, while losing its myeloid characteristics.

我们研究了3例混合型白血病和2例混合表型白血病。 淋巴母细胞性淋巴瘤试图进一步描述它们的特征。这些细胞 对IL-2治疗的反应与正常LAK细胞一样，因为它们会 杀死肿瘤细胞的能力。它们的表型变化类似于 成熟的LAK细胞。利用这些情况，我们提出了正常湖泊 祖细胞是一种T/髓系干细胞，可以通过以下方式分化 IL-2成为成熟的LAK细胞，同时失去其髓系特征。