DEVELOPING INSIGHTS INTO RADIOLABELLED ANTIBODY DOSIMETRY BY COMPUTER SIMULATION

放射性标记的单克隆抗体是指携带放射性， 沉积在肿瘤细胞中。 药物和生理 最终控制抗体实际分布的过程，以及 因此相关的剂量测定是复杂的。 定量成像，两者 空间和时间，放射性核素是一个关键要素作为基础 临床剂量学的一部分。本集团正在努力审查 结合伽马照相机和CT或MRI图像作为基础的潜力 临床剂量学 伽马照相机图像是二维的（2-D） 信息的浓缩，分辨率相对较低，而集合 的CT或MRI切片原则上提供高分辨率的3-D信息 对潜在解剖结构的影响我们的工作包括： A）发展两者之间的计算机联系，使各领域 伽马照相机扫描的兴趣可以定位在3D解剖结构上; B）建立用于确定以下分布的可能性： 在感兴趣的区域下面的层中的放射性。

Radiolabelled monoclonal antibodies are meant to carry radioactivity to be deposited in tumor cells. The pharmaceutical and physiologic processes ultimately governing the actual distribution of antibodies, and thereby the associated dosimetry are complex. Quantitative imaging, both spatial and temporal, of radioactive nuclides is a key element as a basis of clinical dosimetry. our group is engaged in efforts to examine the potential of combining gammacamera and CT or MRI images as a basis of clinical dosimetry. Gammacamera images are 2-dimensional (2-D) condensations of information, with relatively low resolution, while sets of CT or MRI slices provide in principle high resolution 3-D information on the underlying anatomy. our efforts involve: A) the development of computer linkage between the two, so that areas of interest on a gammacamera scan can be located over the 3-D anatomy; B) establishing the potential for determining the distribution of radioactivity in the layers underlying an area of interest.