DEVELOPING INSIGHTS INTO RADIOLABELLED ANTIBODY DOSIMETRY BY COMPUTER SIMULATION

通过计算机模拟深入了解放射性标记抗体剂量测定

• 批准号: 3838066
• 负责人: J VAN DE GEIJN
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838066
• 关键词: antitumor antibody; computed axial tomography; computer simulation; gamma radiation; magnetic resonance imaging; monoclonal antibody; neoplasm /cancer immunotherapy; neoplasm /cancer radionuclide therapy; pharmacokinetics; radiation therapy dosage; radionuclide imaging /scanning; radiopharmacology; radiotracer; scintillation cameras

Radiolabelled monoclonal antibodies are meant to carry radioactivity to be deposited in tumor cells. The pharmaceutical and physiologic processes ultimately governing the actual distribution of antibodies, and thereby the associated dosimetry are complex. Quantitative imaging, both spatial and temporal, of radioactive nuclides is a key element as a basis of clinical dosimetry. our group is engaged in efforts to examine the potential of combining gammacamera and CT or MRI images as a basis of clinical dosimetry. Gammacamera images are 2-dimensional (2-D) condensations of information, with relatively low resolution, while sets of CT or MRI slices provide in principle high resolution 3-D information on the underlying anatomy. our efforts involve: A) the development of computer linkage between the two, so that areas of interest on a gammacamera scan can be located over the 3-D anatomy; B) establishing the potential for determining the distribution of radioactivity in the layers underlying an area of interest.

放射性标记的单抗意在将放射性带到 被沉积在肿瘤细胞中。药学和生理学 最终控制抗体实际分布的过程，以及 因此，相关的剂量学是复杂的。定量成像，两者都是 在空间和时间上，放射性核素是一个关键元素作为基础 临床剂量学。我们的小组正在努力审查 将伽马相机和CT或MRI图像结合起来作为基础的可能性 临床剂量学。Gammacamera图像是二维的(2-D) 信息的浓缩，分辨率相对较低，而集合 的CT或MRI切片原则上提供高分辨率的3D信息 关于潜在的解剖学。我们的工作包括： A)发展两者之间的计算机联系，以便 对伽马相机扫描的兴趣可以在3-D解剖上找到； B)确定确定分配的可能性 感兴趣区域下层中的放射性。