MODELING OF TIME-DOSE RESPONSE OF HUMAN TUMORS AND NORMAL TISSUES

人类肿瘤和正常组织的时间-剂量反应建模

• 批准号: 3874421
• 负责人: J VAN DE GEIJN
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874421
• 关键词: cell population study; cellular oncology; clone cells; computer assisted medical decision making; computer simulation; mathematical model; neoplasm /cancer radiation therapy; nuclear medicine; radiation recovery; radiation sensitivity; radiation therapy dosage; transitional cell carcinoma

The purpose of radiation therapy is tumor control. In view of clonogen proliferation it makes sense to deliver the necessary dose in as short a time as possible. The limiting factor in tumor treatment is normal tissue reaction: normal tissue reactions must not exceed "tolerance" level. The development and application of high technology particularly in computers and computer-based and assisted imaging has stimulated great progress in tumor localization and treatment planning, and even in the technology of delivery and its quality assurance, i.e., the spatial aspects of the issue. Decision-making as to the amount of dose and its distribution over &w (by fractionation or protraction) is still essentially empirical, however. The present project continues the development and exploration of a theoretical description of time-dose response of tumors as well as normal tissues. Its basic concepts have been published in 1988[1]. Since the, further developments have concentrated on extension of the Linear-Quadratic model. This has resulted in some further publications. The extension concerns a unified description of the influence of incomplete repair and comprises a description of the influence of tumor proliferation and stem cell/transition cell repopulation. Currently a study is being completed regarding the implications of high dose arate vs. low dose rate brachytherapy. This work includes the development of an interactive computer program to search for high dose rates comparable with constant tumor control as well as no more severe toxicity.

放射治疗的目的是控制肿瘤。从克隆原的角度看 在最短的时间内提供必要的剂量是有意义的 时间越长越好。肿瘤治疗的限制因素是正常组织 反应：正常的组织反应不得超过“耐受性”水平。这个 高科技特别是计算机技术的发展和应用 以计算机为基础的辅助成像促进了在 肿瘤的定位和治疗计划，甚至在技术上 交付及其质量保证，即问题的空间方面。 关于剂量及其在&W上的分布的决策(通过 然而，分馏或延长)本质上仍然是经验的。这个 本课题继续发展和探索了一种理论 描述肿瘤和正常组织的时间-剂量反应。它的 基本概念已于1988年发表[1]。由于，进一步 发展主要集中在线性二次模型的扩展上。 这导致了一些更多的出版物。延期涉及到一个 对未完成维修的影响的统一描述，包括 肿瘤增殖和干细胞影响的描述 细胞/过渡细胞再繁殖。目前，一项研究正在完成 关于高剂量率与低剂量率的含义 近距离放射治疗。这项工作包括开发一个交互式的 搜索可与常量相比较的高剂量率的计算机程序 肿瘤控制以及没有更严重的毒性。