INFLUENCE OF LUNG DENSITY IN MANTLE TECHNIQUE CHEST IRRADIATION

肺密度对 Mantle 技术胸部照射的影响

• 批准号: 3916604
• 负责人: J VAN DE GEIJN
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3916604
• 关键词: clone cells; computer simulation; cytolysis; mathematical model; neoplasm /cancer radiation therapy; neoplastic cell; radiation dosage; radiation sensitivity; radiobiology

Radiation therapy aims at complete destruction of the proliferative capability of all clonogenic tumor cells, while not exceeding the tolerance for radiation damage to any of the tissues and organs. The biological effects depend on the amount and distribution of absorbed dose. Clinical dosimetry depends almost entirely on an underlying theoretical model. In chest irradiation, the field size, and shape dependent dose distribution is further determined by the size, and shape of the patient, as well as density distribution, and inside the irradiated volume. The need for accurate accounting for the latter is still not unequivocally recognized. The present project is designed to shed new light on this problem. The dosimetry of a large number of patients will be investigated using computer generated dosimetry, as well as relevant measurements.

放射治疗的目的是彻底摧毁增殖性疾病 所有克隆性肿瘤细胞的能力，而不超过 对任何组织和器官的辐射损伤的耐受性。 生物效应取决于其数量和分布。 吸收剂量。临床剂量学几乎完全依赖于 潜在的理论模型。在胸部照射中，野 进一步确定了大小和形状相关的剂量分布 根据患者的大小、形状以及密度 分布，并在辐照体积内。需要 对后者的准确核算仍不是毫不含糊的 被认可了。本项目的目的是为了揭示 这个问题。 将调查大量患者的剂量学 使用计算机生成的剂量学，以及相关的 测量。