CENTER FOR DEVELOPMENTAL IMMUNOLOGY AND HOST DEFENSE

发育免疫学和宿主防御中心

• 批准号: 3103161
• 负责人: Michael M Frank
• 金额: $ 28.66万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103161
• 关键词: autoimmune disorder; biomedical facility; child (0-11); health science research; host organism interaction; hypersensitivity; immunogenetics; immunology; immunoregulation; infection; training

Duke University proposes to establish a Center for the Study of Developmental Immunology and Host Defenses. Disorders of immunity play a major role in many diseases of children, with infectious disease being the most prominent example. During normal host defense against infec- tion, damage-producing elements of the response may impact on normal tissue function. Disorders of immunoregulation are associated with the development of autoimmune and allergic diseases. Genetic diseases of almost all of the components of the host defense system have been described. The Center will have a number of components. Overall direction will be provided by the Chairman of the Department of Pediatrics, Michael M. Frank, M.D., a recognized expert in the area of mediators of tissue damage, who will act as Principal Investigator. Direct day to day supervision will be provided by Rebecca Buckley, a leading pediatric cellular immunologist. A major component of the Center will be a core laboratory which will be directed by Louise Markert, M.D., Ph.D., a molecular biologist with demonstrated expertise in the area of lymphocyte development and control and by Dr. Buckley. The core laboratory will be supplied and equipped for studies using molecular biological, chemical and cellular techniques. This core facility will allow for both training and a portion of the research of the junior faculty investigators supported by this program. These pediatricians will all be within three years of completing their training. It is intended that one more advanced junior faculty investigator be singled out for more support and a greater measure of independence. Part of the Center proposal involves identification and recruitment of suitable potential pediatric investigators. One pool of candidates resides in the participants in the Duke residency and fellowship programs, the majority of whom enter academic pediatrics. Techniques have also been developed to identify and attract individuals not currently part of the Duke program, including minority candidates. The program for successful candidates includes training in a broad array of scientific areas that are part of the immunologic and host defense process. These junior investigators will spend two to three years in the laboratory of well known and established investigators in the Duke community who work in this general area. In this role, they will become trained in the basic science of their field. The purpose of the program is to develop independent young clinical scientists in this field who can then gain academic appointments and independent laboratory support at Duke or elsewhere. An assurance of such an appointment will be a powerful inducement for entering academic pediatrics in this area, where there is currently a very great need nationwide.

杜克大学建议建立一个研究中心， 发育免疫学和宿主防御。 免疫系统紊乱 在许多儿童疾病中起主要作用，传染病是 最突出的例子。 在正常的宿主防御感染过程中， 反应的破坏性因素可能会影响正常的 组织功能 免疫调节障碍与免疫调节相关。 自身免疫性和过敏性疾病的发展。 遗传性疾病 几乎所有的主机防御系统的组成部分， 介绍了 该中心将由若干组成部分组成。 整体 指导将由系主任提供 儿科，Michael M.弗兰克医学博士一个公认的专家在该领域的 组织损伤的介质，谁将担任主要研究者。 直接的日常监督将提供丽贝卡巴克利， 顶尖的儿科细胞免疫学家 该中心的一个主要组成部分 将是一个核心实验室，由医学博士路易丝·马克特（Louise Markert）指导， 哲学博士、一位分子生物学家，在以下领域具有专业知识： 淋巴细胞发育和控制以及巴克利博士。 核心 将提供实验室，并配备使用分子 生物、化学和细胞技术。 该核心设施将 允许培训和初级研究的一部分 由该计划支持的教师调查员。 这些儿科医生 都将在三年内完成训练 是 打算挑选一名高级初级教员调查员 寻求更多的支持和更大程度的独立。 的一部分 中心建议书包括确定和招聘合适的 潜在的儿科研究者 一个候选人库位于 参加杜克住院医师和奖学金计划的人，大多数 进入学术儿科的人 技术也被开发出来 以识别和吸引目前不属于杜克的人 包括少数民族候选人。 成功的方案 候选人包括在广泛的科学领域的培训， 是免疫和宿主防御过程的一部分。 这些小型 研究人员将在油井的实验室里呆上两到三年， 在杜克社区工作的知名调查人员 这片区域。 在这个角色中，他们将接受基础培训 他们领域的科学。 该计划的目的是发展 独立的年轻临床科学家在这一领域谁可以获得 学术任命和独立的实验室支持在杜克或 其他地方 这样的一个任命的保证将是一个强大的 在这个地区进入学术儿科的诱因， 目前全国都有很大的需求。