课题基金 / 基金详情

BARRIER TO XENOTRANSPLANTATION

BARRIER TO XENOTRANSPLANTATION
异种移植的障碍
批准号:
2655251
负责人:
Michael M Frank
金额:
$118.18万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-02-01 至 1999-06-30

项目摘要

项目成果

Michael M Frank的其他基金

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中文摘要
翻译
这个应用程序提出了一个程序化的努力,旨在阐明
英文摘要
This application proposes a programmatic effort aimed at elucidating the immunological barrier to cardiac xenotransplantation and the development of strategies to overcome that barrier. The rationale for this effort is a very critical shortage of human organs available for allotransplantation. The immunological hurdles include hyperacute rejection in unmodified recipients and acute vascular rejection in xenograft recipients who have been unmodified recipients and acute vascular rejection in xenograft recipients who have been depleted of anti-donor antibodies and/or complement. Other hurdles involve graft injury mediated by neutrophils, natural killer cells and lymphocytes. The program uses a preclinical model involving the transplantation of porcine hearts into the cynomolgus monkeys. The contribution to the rejection process of natural antibodies, complement, and inflammatory cells as well as of reperfusion injury, will be addressed. One central theme of the program focuses on endothelial cells as a target of oxidant injury and in humoral and cell mediated responses as an effector system. Another central theme focuses on the acquired resistance of vascularized organ grafts to humoral mediated injury; test the mechanisms which may contribute to this "accommodated" state. Project 1 considers the contribution of oxidant mediated injury of humoral mediated rejection. Project 2 considers the role of natural antibodies and Project 3 considers the role of complement in this process. Project 4 investigates endothelial cell responses to humoral injury. Project 5 explores the contribution of neutrophils to acute vascular rejection. Projects 6 and 7 investigate how natural killer cells and T-lymphocytes, respectively might interact with a xenogeneic organ. Project 8 studies the pathogenesis and potential treatment of humoral rejection in the large animal model. The overall effort of the program is supported by an administrative core and a cell culture and immunopathology core.
期刊论文(12)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1097/00041552-199511000-00002
发表时间: 1995-11-01
期刊: Current opinion in nephrology and hypertension
影响因子: 3.2
作者: [Cardenas, M E, Zhu, D, Heitman, J]
通讯作者: Heitman, J
Calcineurin mutants render T lymphocytes resistant to cyclosporin A.
钙调神经磷酸酶突变体使 T 淋巴细胞对环孢菌素 A 产生抗性。
DOI: --
发表时间: 1996
期刊: Molecular pharmacology.
影响因子: --
作者: [Zhu,D, Cardenas,ME, Heitman,J]
通讯作者: Heitman,J
vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.
酿酒酵母的 vph6 突变体需要钙调神经磷酸酶才能生长,并且在液泡 H(+)-ATP 酶组装方面存在缺陷。
DOI: 10.1093/genetics/141.3.833
发表时间: 1995
期刊: Genetics
影响因子: 3.3
作者: [Hemenway,CS, Dolinski,K, Cardenas,ME, Hiller,MA, Jones,EW, Heitman,J]
通讯作者: Heitman,J
The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches.
L-选择素、β7 整合素和 P-选择素在派尔氏集结高内皮微静脉中白细胞滚动和粘附中的作用。
DOI: --
发表时间: 1998
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者: [Kunkel,EJ, Ramos,CL, Steeber,DA, Muller,W, Wagner,N, Tedder,TF, Ley,K]
通讯作者: Ley,K
Complement Regulates the Humoral Response to HIV-1
  • 批准号:
    7764750
  • 项目类别:
  • 资助金额:
    $23.17万
  • 财政年份:
    2009
  • 负责人:
    Michael M Frank
  • 依托单位:
Complement Regulates the Humoral Response to HIV-1
  • 批准号:
    7685184
  • 项目类别:
  • 资助金额:
    $19.5万
  • 财政年份:
    2009
  • 负责人:
    Michael M Frank
  • 依托单位:
Center for Molecular & Cellular Studies of Ped Disease
  • 批准号:
    6579068
  • 项目类别:
  • 资助金额:
    $43.09万
  • 财政年份:
    2003
  • 负责人:
    Michael M Frank
  • 依托单位:
Center for Molecular & Cellular Studies of Ped Disease
  • 批准号:
    6736329
  • 项目类别:
  • 资助金额:
    $43.2万
  • 财政年份:
    2003
  • 负责人:
    Michael M Frank
  • 依托单位:
海外基金