EXPERIMENTAL DESIGN AND DATA ANALYSIS METHODOLOGY FOR ANIMAL EXPERIMENTS

这个项目关注的是统计方法问题 实验动物实验的设计、分析和解释。 一项调查表明，虽然有显著的 化学毒性之间的相关性(以最大值衡量 耐受量)和啮齿动物致癌性，这种相关性似乎 主要局限于灌胃研究。此外，一种新的 化学物质似乎不是一个可靠的预测指标 化学物质将成为啮齿动物的致癌物质。考虑进行的另一项调查 化学物质特定部位致癌效应之间的相关性 在大鼠和小鼠的NTP长期研究中进行了测试。对于某些站点 (例如，前胃)性别和性别之间存在显著的相关性 物种，即产生这些特定肿瘤的化学物质往往 增加雄性和雌性以及大鼠和大鼠的这些肿瘤 老鼠。总体而言，一种产生特定部位致癌作用的化学品 在一个性别中有大约65%的机会产生同样的效果 同样，在另一个性别中，大约有36%的变化 一种在一种物种中产生致癌作用的化学物质将产生 在其他物种中也有同样的特定部位效应。未来研究 与该项目相关的内容包括对错误频率的估计 长期解释中的阳性和假阴性结果 啮齿动物致癌性研究。

This project is concerned with statistical methodology issues in the design, analysis, and interpretation of laboratory animal experiments. One investigation demonstrated that while there is a significant correlation between chemical toxicity (as measured by the maximum tolerated dose) and rodent carcinogenicity, this correlation seems limited primarily to gavage studies. Further, the toxicity of a chemical does not seem to be a reliable predictor of whether or not a chemical will be a rodent carcinogen. Another investigation considered the correlation between site-specific carcinogenic effects for chemicals tested in NTP long term studies in rats and mice. For certain sites (e.g., forestomach) there were striking correlations between sexes and species, i.e., chemicals producing these particular tumors tended to increase these neoplasms in both males and females and in both rats and mice. Overall, a chemical producing a site-specific carcinogenic effect in one sex had approximately a 65% chance of producing that same effect in the other sex; similarly, there was approximately a 36% change that a chemical producing a carcinogenic effect in one species would produce that same site-specific effect in the other species. Future research related to this project includes an estimation of the frequency of false positive and false negative outcomes in the interpretation of long term rodent carcinogenicity studies.