EXPERIMENTAL DESIGN AND DATA ANALYSIS METHODOLOGY FOR ANIMAL EXPERIMENTS

该项目涉及以下方面的统计方法问题： 实验室动物实验的设计、分析和解释， 特别强调两年的致癌性研究。 实验 设计问题包括使用最大耐受剂量（MTD）和 可能利用多个并发控制组， 致癌性研究。 数据分析领域的研究集中在 使用逻辑回归技术分析非致命性肿瘤， 建模肿瘤发病分布，并评估协同 在致癌性试验中的作用。 影响《公约》的统计问题 致癌性研究的解释包括评价总体错误 阳性率和评估相关的生物学意义 肿瘤反应。

This project is concerned with statistical methodology issues involved in the design, analysis, and interpretation of laboratory animal experiments, with particular emphasis on two-year carcinogenicity studies. Experimental design issues include the use of the maximum tolerated dose (MTD) and the possible utilization of multiple concurrent control groups in carcinogenicity studies. Research in the area of data analysis has focused on the use of logistic regression techniques to analyze non-fatal tumors, modeling tumor onset distributions, and the assessment of synergistic effects in carcinogenicity testing. Statistical issues affecting the interpretation of carcinogenicity studies include evaluating overall false positive rates and assessing the biological significance of correlated tumor responses.