EXPERIMENTAL DESIGN AND DATA ANALYSIS METHODOLOGY FOR ANIMAL EXPERIMENTS

本项目涉及统计学的应用 实验室动物实验方法，特别是 强调长期致癌性研究。 具体领域 这是过去一年研究工作的重点 包括实验设计（例如，选择适当的剂量 水平;使用双重对照组），数据分析（例如，的影响 肿瘤和治疗致死率对肿瘤剂量相关趋势的影响 发病;开发不需要病因的新方法 死亡信息;评估致癌性研究中的协同作用）， 以及结果的解释（例如，评估身体的影响 肿瘤发生率的体重和时间相关趋势;评估 肿瘤反应中的种间相关性）。 其他研究 这些努力包括评估 毒性/遗传毒性和化学诱导致癌作用 实验室啮齿动物，并调查可能的影响， 评价化学品对肝肿瘤发生率的笼效应， 肝致癌物。 其中许多调查利用了 实验室动物致癌性研究的大型数据库 由国家毒理学计划进行。

This project is concerned with the application of statistical methodology to laboratory animal experiments, with particular emphasis on long-term carcinogenicity studies. Specific areas that were the focus of research efforts during the past year included experimental design (e.g., selection of appropriate dose levels; use of dual control groups), data analysis (e.g., effect of tumor and treatment lethality on dose-related trends in tumor onset; developing new methodology that does not require cause of death information; assessing synergism in carcinogenicity studies), and interpretation of results (e.g., evaluating the effects of body weight, and time-related trends on tumor incidence; assessing inter-species correlation in neoplastic response). Other research efforts included assessing the relationship between toxicity/genotoxicity and chemically induced carcinogenesis in laboratory rodents, and investigating the possible influences of cage effects on liver tumor incidence for chemicals evaluated as hepatocarcinogens. Many of these investigations utilized the large data base of laboratory animal carcinogenicity studies carried out by the National Toxicology Program.