EXPERIMENTAL DESIGN AND DATA ANALYSIS METHODOLOGY FOR ANIMAL EXPERIMENTS

该项目涉及统计学的应用。 实验动物实验的方法学，特别是 重视长期致癌性研究。特定领域 这些都是过去一年研究工作的重点 包括实验设计(例如，选择适当的剂量 水平；双重控制组的使用)、数据分析(例如 肿瘤和治疗致死率与肿瘤剂量相关趋势 开始；开发不需要原因的新方法 死亡信息；在致癌性研究中评估协同作用) 以及对结果的解释(例如，评估身体的效果 体重和肿瘤发病率的时间相关趋势；评估 肿瘤反应中的物种间相关性)。其他研究 努力包括评估两国之间的关系 毒性/遗传毒性和化学致癌作用 实验室啮齿动物，并调查可能的影响 化学品对肝脏肿瘤发病率的笼子效应评估如下 致癌物质。这些调查中的许多都利用了 实验动物致癌性研究大型数据库 由国家毒理学计划进行。

This project is concerned with the application of statistical methodology to laboratory animal experiments, with particular emphasis on long-term carcinogenicity studies. Specific areas that were the focus of research efforts during the past year included experimental design (e.g., selection of appropriate dose levels; use of dual control groups), data analysis (e.g., effect of tumor and treatment lethality on dose-related trends in tumor onset; developing new methodology that does not require cause of death information; assessing synergism in carcinogenicity studies), and interpretation of results (e.g., evaluating the effects of body weight, and time-related trends on tumor incidence; assessing inter-species correlation in neoplastic response). Other research efforts included assessing the relationship between toxicity/genotoxicity and chemically induced carcinogenesis in laboratory rodents, and investigating the possible influences of cage effects on liver tumor incidence for chemicals evaluated as hepatocarcinogens. Many of these investigations utilized the large data base of laboratory animal carcinogenicity studies carried out by the National Toxicology Program.