黄化激素释放激素系统的个体发育-猫眼课题宝

黄化激素释放激素系统的个体发育

批准号：

3846300

负责人：

S WRAY

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3846300

关键词：

cell migration central nervous system developmental neurobiology ectoderm embryo /fetus tissue /cell culture fibronectins gene expression genetically modified animals laboratory mouse neural cell adhesion molecules neurons posttranslational modifications

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英文摘要

LHRH neurons are derived from the olfactory placode and migrate into the brain. The factors which dictate cell-specific LHRH gene expression and the migratory mechanism(s) used by the LHRH neurons during their movement in the CNS are currently unknown. Using in vivo and in vitro models, we are examining the prenatal development of the LHRH system. We are testing the hypothesis that N-CAM and fibronectin direct LHRH movement in nasal regions by using embryonic explants which maintain large numbers of LHRH expressing cells. In addition, we have found that LHRH cells do not posttranslationally modify LHRH to the amidated form in vivo until reaching the forebrain. Embryonic LHRH cells derived from nasal regions were able to produce the "mature" peptide in vitro in the absence of brain tissue, suggesting that this is a time-dependent (but not spatially-dependent) event.

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