IMMUNOSUPPRESSIVE THERAPY IN MOTOR NEURON DISORDERS

运动神经元疾病的免疫抑制治疗

• 批准号: 3847359
• 负责人: JERRY R MENDELL
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3847359
• 关键词: autoantibody; degenerative motor system disease; gangliosides; human subject; human therapy evaluation; immunosuppressive; monoclonal antibody; nervous system disorder chemotherapy; prognosis

The aims of this study are to (1) determine is there is a subset of motor neuron disorders that respond to immunosuppressive therapy; (2) to determine what if any clinical features are predictive of treatment outcome with immunosuppressive therapy; and (3) establish the frequency of antiganglioside antibodies, multifocal motor conduction block and monoclonal gammopathies in patients with motor neuron syndromes.

本研究的目的是 (1) 确定是否存在一个子集 对免疫抑制治疗有反应的运动神经元疾病； (2) 至 确定是否有任何临床特征可以预测治疗 免疫抑制治疗的结果； (3) 确定频率 抗神经节苷脂抗体、多灶性运动传导阻滞和 运动神经元综合征患者的单克隆丙种球蛋白病。