Defining the apoptotic and therapeutic activities of histone deacetylase inhibitors.

定义组蛋白脱乙酰酶抑制剂的细胞凋亡和治疗活性。

• 批准号: nhmrc : 566702
• 负责人: Prof Ricky Johnstone
• 金额: $ 35.13万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-apoptotic-therapeutic-deacetylase-inhibitors/100124
• 关键词: Defining; apoptotic; therapeutic; activities; histone

HDAC inhibitors (HDACi) are new chemotherapeutic drugs that kill tumors cells through a cell suicide process called apoptosis. We have now established a mouse model of human lymphoma whereby pro-apoptotic proteins have been eliminated or anti-apoptotic proteins overexpressed. We will identify the apoptotic proteins and pathways that are necessary for HDACi to kill cancer cells. Such information will lead to a more targeted or rational approach to chemotherapy using HDACi.

HDAC抑制剂（HDACi）是一种新型的化疗药物，通过称为凋亡的细胞自杀过程杀死肿瘤细胞。我们现在已经建立了人类淋巴瘤的小鼠模型，其中促凋亡蛋白已被消除或抗凋亡蛋白过表达。我们将确定HDACi杀死癌细胞所必需的凋亡蛋白和途径。这些信息将导致使用HDACi进行化疗的更有针对性或更合理的方法。