Cancer Genetics, epigenetics and targeted therapies

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I aim to gain greater insight into how blood cancers arise and how we should ultimately treat patients with these diseases. I will identify the genetic defects that underpin the development of blood cancers, how these genetic defects de-regulate gene expression through so-called “epigenetic” changes to allow these abnormal blood cells grow and survive. I will test the activity of small molecules that interfere with the cancer-causing epigenetic and signaling pathways in experimental models.