Cancer Genetics, epigenetics and targeted therapies

癌症遗传学、表观遗传学和靶向治疗

• 批准号: nhmrc : 1077867
• 负责人: Prof Ricky Johnstone
• 金额: $ 58.26万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cancer-genetics-epigenetics-targeted-therapies/518539
• 关键词: Cancer; Genetics; epigenetics; targeted; therapies

I aim to gain greater insight into how blood cancers arise and how we should ultimately treat patients with these diseases. I will identify the genetic defects that underpin the development of blood cancers, how these genetic defects de-regulate gene expression through so-called “epigenetic” changes to allow these abnormal blood cells grow and survive. I will test the activity of small molecules that interfere with the cancer-causing epigenetic and signaling pathways in experimental models.

我的目标是更深入地了解血癌是如何产生的，以及我们最终应该如何治疗这些疾病的患者。我将确定支持血癌发展的遗传缺陷，这些遗传缺陷如何通过所谓的“表观遗传”变化来解除基因表达的调节，从而使这些异常血细胞生长和存活。我将在实验模型中测试干扰致癌表观遗传和信号通路的小分子的活性。