Defining the anterograde and endocytic trafficking pathways in primary neurons; relevance to dysfunctional trafficking of BACE1 and APP in Alzheimer’s disease

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Alzheimer’s disease results from toxic peptides arising from the cleavage of a large molecule called APP in the brain. The production of toxic peptides is normally regulated by the transport of APP molecules between compartments inside the cell. In Alzheimer’s disease, the APP transport pathways are altered leading to high levels of toxic peptide.This research will discover the basis for the altered transport of APP in disease, information which could allow new approaches for dementia treatment.