Defining the anterograde and endocytic trafficking pathways in primary neurons; relevance to dysfunctional trafficking of BACE1 and APP in Alzheimer’s disease

定义原代神经元的顺行和内吞运输途径；

• 批准号: nhmrc : GNT1163862
• 金额: $ 67.49万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-anterograde-endocytic-alzheimers-disease/1379324
• 关键词: Defining; anterograde; endocytic; trafficking; pathways

Alzheimer’s disease results from toxic peptides arising from the cleavage of a large molecule called APP in the brain. The production of toxic peptides is normally regulated by the transport of APP molecules between compartments inside the cell. In Alzheimer’s disease, the APP transport pathways are altered leading to high levels of toxic peptide.This research will discover the basis for the altered transport of APP in disease, information which could allow new approaches for dementia treatment.

阿尔茨海默病是由大脑中一种叫做APP的大分子分裂产生的有毒肽引起的。毒性肽的产生通常由APP分子在细胞内隔室之间的运输调节。在阿尔茨海默病中，APP运输途径发生改变，导致高水平的毒性肽。这项研究将发现疾病中APP转运改变的基础，这些信息可能为痴呆症治疗提供新的方法。