BIOSYNTHETICALLY 13C-LABELED TRIGLYCERIDE IN LIPID OXIDATION STUDIES

脂质氧化研究中的生物合成 13C 标记甘油三酯

• 批准号: 3850395
• 负责人: PETER KLEIN
• 金额: --
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3850395
• 关键词: body composition; carbon; enzyme activity; fats; human subject; lipid metabolism; lipoprotein lipase; oleate; oxidation; stable isotope; triglycerides

1) To determine the degree of oxidation of two biosynthetically derived triglycerides containing a high proportion of 13c-labeled oleic acid as compared to the oxidation of a synthetic triglyceride containing all 1-13c-oleic acid, a more expensive 13c substrate. 2) Characterization of fat oxidation by the study population with respect to total body fat as determined from total body measurement and by quantification of lipoprotein lipase activity.

1)为了确定两种生物合成衍生物的氧化程度， 含有高比例的13C-标记的油酸的甘油三酯， 与含有全部的合成甘油三酯的氧化相比， 1 - 13 C-油酸，更昂贵的13 C底物。2)表征 研究人群的脂肪氧化相对于总体脂， 通过全身测量和定量测定 脂蛋白脂酶活性