CORD BLOOD DIAGNOSIS OF COAGULOPATHIES IN HIGH-RISK NEWBORNS

高危新生儿凝血病的脐带血诊断

• 批准号: 3848894
• 负责人: MARILYN J MANCO-JOHNSON
• 金额: --
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3848894
• 关键词: blood coagulation tests; blood disorder diagnosis; diagnosis design /evaluation; disseminated intravascular coagulation; fibrin; fibrinogen; human subject; newborn human (0-6 weeks); plasmin; thrombin

Coagulopathies occur frequently in the sick newborn but are difficult to diagnose because of insensitivities in our current screening tests. This study will measure specific fibrinogen/fibrin fragments to develop a more specific and sensitive test of disseminated intravascular coagulation (DIC) and to discern the role of thrombin activation and/or plasmin degradation in the pathogenesis of DC in high-risk newborns.

凝固性疾病在患病的新生儿中经常发生，但很难 诊断是因为我们目前的筛查测试不敏感。 这项研究将测量特定的纤维蛋白原/纤维蛋白片段以开发 一种更特异、更敏感的播散性血管内凝血试验 凝血(DIC)和辨别凝血酶激活和/或 纤溶酶降解在高危新生儿DC发病机制中的作用