Defining the cellular and molecular pathways leading to peanut allergy in children

定义导致儿童花生过敏的细胞和分子途径

• 批准号: nhmrc : GNT1165073
• 金额: $ 102.36万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-cellular-molecular-allergy-children/1379383
• 关键词: Defining; cellular; molecular; pathways; leading

Food allergies are now a major public health problem in Australia, affecting one in ten children. Prevention and treatment is hindered by a lack of understanding of how genes and environment interact in early life to 'biologically embed' the risk of disease. In this study we will comprehensively characterise the immune dysfunction and underlying mechanisms from early infancy using a variety of state-of-the-art laboratory and analysis approaches.

食物过敏现在是澳大利亚的一个主要公共卫生问题，影响着十分之一的儿童。由于缺乏对基因和环境在生命早期如何相互作用以“生物学地嵌入”疾病风险的了解，阻碍了预防和治疗。在这项研究中，我们将使用各种最先进的实验室和分析方法，全面描述婴儿早期的免疫功能障碍和潜在机制。